LOCUS CCP44053.1 316 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable homoserine kinase
ThrB protein.
ACCESSION AL123456-1331
PROTEIN_ID CCP44053.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="thrB"
/locus_tag="Rv1296"
/note="Rv1296, (MTCY373.16), len: 316 aa. Probable
thrB,homoserine kinase (see citation below), highly
similar to KHSE_MYCLE|P45836 from Mycobacterium leprae
(314 aa), FASTA scores, opt: 1657, E(): 0, (82.0% identity
in 311 aa overlap). Contains PS00639 Eukaryotic thiol
(cysteine) proteases histidine active site, and PS00627
GHMP kinases putative ATP-binding domain."
/db_xref="EnsemblGenomes-Gn:Rv1296"
/db_xref="EnsemblGenomes-Tr:CCP44053"
/db_xref="GOA:P9WKE7"
/db_xref="InterPro:IPR000870"
/db_xref="InterPro:IPR006203"
/db_xref="InterPro:IPR006204"
/db_xref="InterPro:IPR014721"
/db_xref="InterPro:IPR020568"
/db_xref="InterPro:IPR036554"
/db_xref="UniProtKB/Swiss-Prot:P9WKE7"
/inference="protein motif:PROSITE:PS00639"
/inference="protein motif:PROSITE:PS00627"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MVTQALLPSG LVASAVVAAS SANLGPGFDS VGLALSLYDE IIVETTDSGL TVTVDGEGGD
61 QVPLGPEHLV VRAVQHGLQA AGVSAAGLAV RCRNAIPHSR GLGSSAAAVV GGLAAVNGLV
121 VQTDSSPSSD AELIQLASEF EGHPDNAAAA VLGGAVVSWT DHSGDRPNYS AVSLRLHPDI
181 RLFTAIPEQR SSTAETRVLL PAQVSHDDAR FNVSRAALLV VALTERPDLL MAATEDLLHQ
241 PQRAAAMTAS AEYLRLLRRH NVAAALSGAG PSLIALSTDS ELPTDAVEFG AAKGFAVTEL
301 TVGEAVRWSP TVRVPG
//