LOCUS CCP43847.1 275 aa PRT BCT 27-FEB-2015 DEFINITION Mycobacterium tuberculosis H37Rv Possible acyl-[acyl-carrier protein] desaturase DesA2 (acyl-[ACP] desaturase) (stearoyl- ACP desaturase) protein. ACCESSION AL123456-1125 PROTEIN_ID CCP43847.1 SOURCE Mycobacterium tuberculosis H37Rv ORGANISM Mycobacterium tuberculosis H37Rv Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J., Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. TITLE Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence JOURNAL Nature 393(6685), 537-544(1998). PUBMED 9634230 REMARK Erratum:[Nature 1998 Nov 12;396(6707):190] REFERENCE 2 AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T. TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002). PUBMED 12368430 REFERENCE 3 AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. TITLE TubercuList--10 years after JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011). PUBMED 20980199 REFERENCE 4 (bases 1 to 4411529) AUTHORS Parkhill J. JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the Mycobacterium tuberculosis sequencing and mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: parkhill@sanger.ac.uk REFERENCE 5 (bases 1 to 4411532) AUTHORS Lew J.M. JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva 4, SWITZERLAND COMMENT On or before Feb 1, 2013 this sequence version replaced gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250, gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756, gi:38490319, gi:41352785, gi:38490370, gi:41353971. Note: This annotation is from the TubercuList website, Release 26, Dec 2012 (URL: http://tuberculist.epfl.ch) (email: tuberculist@epfl.ch). FEATURES Qualifiers source /organism="Mycobacterium tuberculosis H37Rv" /strain="H37Rv" /mol_type="genomic DNA" /db_xref="taxon:83332" protein /transl_table=11 /gene="desA2" /locus_tag="Rv1094" /note="Rv1094, (MTV017.47), len: 275 aa. Possible desA2,acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase), equivalent to AL049491|MLCB1222_15 from Mycobacterium leprae (275 aa), FASTA score: (78.1% identity in 274 aa overlap). Also weakly similar to plant stearoyl-acyl carrier protein desaturases, and very similar to U49839|MTV043.16C|Rv0824c enzyme desA1 from Mycobacterium tuberculosis (338 aa), FASTA scores: opt: 525, E(): 8.5e-30, (32.2% identity in 270 aa overlap); and to U15182|MLU15182_32 acyl-carrier protein desaturase precursor from Mycobacterium leprae (338 aa), FASTA scores: opt: 506, E(): 1.9e-28, (34.1% identity in 261 aa overlap)." /db_xref="EnsemblGenomes-Gn:Rv1094" /db_xref="EnsemblGenomes-Tr:CCP43847" /db_xref="GOA:P9WNZ5" /db_xref="InterPro:IPR005067" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012348" /db_xref="PDB:1ZA0" /db_xref="UniProtKB/Swiss-Prot:P9WNZ5" /experiment="EXISTENCE: identified in proteomics study" BEGIN 1 MAQKPVADAL TLELEPVVEA NMTRHLDTED IWFAHDYVPF DQGENFAFLG GRDWDPSQST 61 LPRTITDACE ILLILKDNLA GHHRELVEHF ILEDWWGRWL GRWTAEEHLH AIALREYLVV 121 TREVDPVANE DVRVQHVMKG YRAEKYTQVE TLVYMAFYER CGAVFCRNLA AQIEEPILAG 181 LIDRIARDEV RHEEFFANLV THCLDYTRDE TIAAIAARAA DLDVLGADIE AYRDKLQNVA 241 DAGIFGKPQL RQLISDRITA WGLAGEPSLK QFVTG //