LOCUS       CCP43828.1               464 aa    PRT              BCT 27-FEB-2015
DEFINITION  Mycobacterium tuberculosis H37Rv Probable cystathionine
            beta-synthase Cbs (serine sulfhydrase) (beta-thionase)
            (hemoprotein H-450) protein.
ACCESSION   AL123456-1106
PROTEIN_ID  CCP43828.1
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
            Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
            Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
            Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
            Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
            Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
            Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
            Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
            Barrell B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393(6685), 537-544(1998).
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   2
  AUTHORS   Camus J.C., Pryor M.J., Medigue C., Cole S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
   PUBMED   12368430
REFERENCE   3
  AUTHORS   Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
  TITLE     TubercuList--10 years after
  JOURNAL   Tuberculosis (Edinb) 91(1), 1-7(2011).
   PUBMED   20980199
REFERENCE   4  (bases 1 to 4411529)
  AUTHORS   Parkhill J.
  JOURNAL   Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
            Mycobacterium tuberculosis sequencing and mapping teams, Sanger
            Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
            Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
            rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
            parkhill@sanger.ac.uk
REFERENCE   5  (bases 1 to 4411532)
  AUTHORS   Lew J.M.
  JOURNAL   Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
            Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
            Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
            4, SWITZERLAND
COMMENT     On or before Feb 1, 2013 this sequence version replaced
            gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
            gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
            gi:38490319, gi:41352785, gi:38490370, gi:41353971.
            Note:
            This annotation is from the TubercuList website, Release 26, Dec
            2012 (URL: http://tuberculist.epfl.ch) (email:
            tuberculist@epfl.ch).
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37Rv"
                     /strain="H37Rv"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:83332"
     protein         /transl_table=11
                     /gene="cbs"
                     /gene_synonym="cysM2"
                     /locus_tag="Rv1077"
                     /note="Rv1077, (MTV017.30), len: 464 aa. Probable cbs
                     (previously cysM2), cystathionine beta-synthase, similar
                     throughout its length to many eukaryotic cystathionine
                     beta-synthases e.g. P32232|CBS_RAT cystathionine
                     beta-synthase (560 aa), FASTA scores: opt: 951, E():
                     0,(40.2% identity in 450 aa overlap); also similar in
                     N-terminal domain (aa 1 - 330) to Rv2334|MTCY98.03 CysK
                     Mycobacterium tuberculosis (310 aa), FASTA scores: opt:
                     855, E(): 0, (46.8% identity in 314 overlap); and other
                     cysteine synthase proteins e.g. Rv1336, Rv0848, etc.
                     Contains PS00217 Sugar transport proteins signature 2
                     probably spurious. Belongs to the cysteine
                     synthase/cystathionine beta-synthase family."
                     /db_xref="EnsemblGenomes-Gn:Rv1077"
                     /db_xref="EnsemblGenomes-Tr:CCP43828"
                     /db_xref="GOA:P9WP51"
                     /db_xref="InterPro:IPR000644"
                     /db_xref="InterPro:IPR001926"
                     /db_xref="InterPro:IPR005857"
                     /db_xref="InterPro:IPR036052"
                     /db_xref="UniProtKB/Swiss-Prot:P9WP51"
                     /inference="protein motif:PROSITE:PS00217"
                     /experiment="EXISTENCE: identified in proteomics study"
BEGIN
        1 MRIAQHISEL IGGTPLVRLN SVVPDGAGTV AAKVEYLNPG GSSKDRIAVK MIEAAEASGQ
       61 LKPGGTIVEP TSGNTGVGLA LVAQRRGYKC VFVCPDKVSE DKRNVLIAYG AEVVVCPTAV
      121 PPHDPASYYS VSDRLVRDID GAWKPDQYAN PEGPASHYVT TGPEIWADTE GKVTHFVAGI
      181 GTGGTITGAG RYLKEVSGGR VRIVGADPEG SVYSGGAGRP YLVEGVGEDF WPAAYDPSVP
      241 DEIIAVSDSD SFDMTRRLAR EEAMLVGGSC GMAVVAALKV AEEAGPDALI VVLLPDGGRG
      301 YMSKIFNDAW MSSYGFLRSR LDGSTEQSTV GDVLRRKSGA LPALVHTHPS ETVRDAIGIL
      361 REYGVSQMPV VGAEPPVMAG EVAGSVSERE LLSAVFEGRA KLADAVSAHM SPPLRMIGAG
      421 ELVSAAGKAL RDWDALMVVE EGKPVGVITR YDLLGFLSEG AGRR
//