LOCUS CCP43828.1 464 aa PRT BCT 27-FEB-2015 DEFINITION Mycobacterium tuberculosis H37Rv Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) protein. ACCESSION AL123456-1106 PROTEIN_ID CCP43828.1 SOURCE Mycobacterium tuberculosis H37Rv ORGANISM Mycobacterium tuberculosis H37Rv Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J., Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. TITLE Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence JOURNAL Nature 393(6685), 537-544(1998). PUBMED 9634230 REMARK Erratum:[Nature 1998 Nov 12;396(6707):190] REFERENCE 2 AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T. TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002). PUBMED 12368430 REFERENCE 3 AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. TITLE TubercuList--10 years after JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011). PUBMED 20980199 REFERENCE 4 (bases 1 to 4411529) AUTHORS Parkhill J. JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the Mycobacterium tuberculosis sequencing and mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: parkhill@sanger.ac.uk REFERENCE 5 (bases 1 to 4411532) AUTHORS Lew J.M. JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva 4, SWITZERLAND COMMENT On or before Feb 1, 2013 this sequence version replaced gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250, gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756, gi:38490319, gi:41352785, gi:38490370, gi:41353971. Note: This annotation is from the TubercuList website, Release 26, Dec 2012 (URL: http://tuberculist.epfl.ch) (email: tuberculist@epfl.ch). FEATURES Qualifiers source /organism="Mycobacterium tuberculosis H37Rv" /strain="H37Rv" /mol_type="genomic DNA" /db_xref="taxon:83332" protein /transl_table=11 /gene="cbs" /gene_synonym="cysM2" /locus_tag="Rv1077" /note="Rv1077, (MTV017.30), len: 464 aa. Probable cbs (previously cysM2), cystathionine beta-synthase, similar throughout its length to many eukaryotic cystathionine beta-synthases e.g. P32232|CBS_RAT cystathionine beta-synthase (560 aa), FASTA scores: opt: 951, E(): 0,(40.2% identity in 450 aa overlap); also similar in N-terminal domain (aa 1 - 330) to Rv2334|MTCY98.03 CysK Mycobacterium tuberculosis (310 aa), FASTA scores: opt: 855, E(): 0, (46.8% identity in 314 overlap); and other cysteine synthase proteins e.g. Rv1336, Rv0848, etc. Contains PS00217 Sugar transport proteins signature 2 probably spurious. Belongs to the cysteine synthase/cystathionine beta-synthase family." /db_xref="EnsemblGenomes-Gn:Rv1077" /db_xref="EnsemblGenomes-Tr:CCP43828" /db_xref="GOA:P9WP51" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005857" /db_xref="InterPro:IPR036052" /db_xref="UniProtKB/Swiss-Prot:P9WP51" /inference="protein motif:PROSITE:PS00217" /experiment="EXISTENCE: identified in proteomics study" BEGIN 1 MRIAQHISEL IGGTPLVRLN SVVPDGAGTV AAKVEYLNPG GSSKDRIAVK MIEAAEASGQ 61 LKPGGTIVEP TSGNTGVGLA LVAQRRGYKC VFVCPDKVSE DKRNVLIAYG AEVVVCPTAV 121 PPHDPASYYS VSDRLVRDID GAWKPDQYAN PEGPASHYVT TGPEIWADTE GKVTHFVAGI 181 GTGGTITGAG RYLKEVSGGR VRIVGADPEG SVYSGGAGRP YLVEGVGEDF WPAAYDPSVP 241 DEIIAVSDSD SFDMTRRLAR EEAMLVGGSC GMAVVAALKV AEEAGPDALI VVLLPDGGRG 301 YMSKIFNDAW MSSYGFLRSR LDGSTEQSTV GDVLRRKSGA LPALVHTHPS ETVRDAIGIL 361 REYGVSQMPV VGAEPPVMAG EVAGSVSERE LLSAVFEGRA KLADAVSAHM SPPLRMIGAG 421 ELVSAAGKAL RDWDALMVVE EGKPVGVITR YDLLGFLSEG AGRR //