LOCUS CCP43825.1 405 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable beta-ketoacyl
CoA thiolase FadA3 protein.
ACCESSION AL123456-1103
PROTEIN_ID CCP43825.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="fadA3"
/locus_tag="Rv1074c"
/note="Rv1074c, (MTV017.27c), len: 405 aa. Probable
fadA3,beta-ketoacyl CoA thiolase, highly similar to many
involved in beta-oxidation e.g. CAB89028.1|AL353870
beta-ketoadipyl-CoA thiolase from Streptomyces coelicolor
(395 aa); P77525|PAAJ_ECOLI probable beta-ketoadipyl CoA
thiolase from Escherichia coli (401 aa), FASTA scores:
opt: 1034, E(): 5.4e-56, (43.5% identity in 416 aa
overlap) and X97452 acetyl-CoA acetyltransferase
(thiolase) from Escherichia coli (401 aa), FASTA scores:
opt: 1043, E(): 0,(43.4% identity in 415 aa overlap);
Q43935|CATF_ACICA beta-ketoadipyl CoA thiolase from
Acinetobacter calcoaceticus (401 aa), FASTA scores: opt:
992, E(): 0,(41.5% identity in 415 aa overlap); etc.
Contains PS00737 Thiolases signature 2, and PS00445 FGGY
family of carbohydrate kinases signature 2, although this
is probably fortuitous. Belongs to the thiolase family."
/db_xref="EnsemblGenomes-Gn:Rv1074c"
/db_xref="EnsemblGenomes-Tr:CCP43825"
/db_xref="GOA:O53422"
/db_xref="InterPro:IPR002155"
/db_xref="InterPro:IPR016039"
/db_xref="InterPro:IPR020613"
/db_xref="InterPro:IPR020616"
/db_xref="InterPro:IPR020617"
/db_xref="UniProtKB/TrEMBL:O53422"
/inference="protein motif:PROSITE:PS00737"
/inference="protein motif:PROSITE:PS00445"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MPEAVIVSTA RSPIGRAMKG SLVGMRPDDL AVQMVRAALD KVPALNPHQI DDLMMGCGLP
61 GGESGFNIAR VVAVALGYDF LPGTTVNRYC SSSLQTTRMA FHAIKAGEGD AFISAGVETV
121 SRFAKGNSDS WPDTKNPLFD GAQERSAAAA AGADEWHDPR TDQKLPDIYI AMGQTAENVA
181 IMTGISREEQ DRWGVRSQNR AEEAIKNGFF EREITPVTLP DGTTVSTDDG PRPGTTYEKV
241 SELKPAFRPN GTVTAGNACP LNDGAAAVVI TSDTKAKELG LTPLARIVST GVSGLSPEIM
301 GLGPIEASKK ALERAGMAIT DIDLVEINEA FAVQVLGSAR ELGIDEDKLN ISGGAIALGH
361 PFGMTGARIT TTLLNNLQTY DKTFGLETMC VGGGQGMAMV IERLA
//