LOCUS CCP43733.1 464 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable serine protease
PepD (serine proteinase) (MTB32B) protein.
ACCESSION AL123456-1011
PROTEIN_ID CCP43733.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="pepD"
/gene_synonym="mtb32b"
/locus_tag="Rv0983"
/note="Rv0983, (MTV044.11), len: 464 aa. Probable pepD
(alternate gene name: mtb32b), secreted or membrane serine
protease (see citation below), equivalent (but longer 18
aa in N-terminus) to AL035500|MLCL373_17|T45448 probable
serine proteinase from Mycobacterium leprae (452 aa),
FASTA score: (74.2% identity in 466 aa overlap); and
highly similar to others from Mycobacterium leprae. Also
highly similar (except in N-terminus) to other proteases
e.g. CAC01350.1|AL390975 putative protease from
Streptomyces coelicolor (542 aa);
NP_440705.1|NC_000911|HtrA serine protease from
Synechocystis sp. (452 aa); NP_346646.1|NC_003028 serine
protease from Streptococcus pneumoniae (393 aa); etc. Also
similar in part to members of the htrA-antigen family e.g.
U87242|MTU87242_3|HtrA serine protease from M.
tuberculosis (542 aa), FASTA scores: opt: 846, E(): 2e-28,
(40.6% identity in 392 aa overlap); and similar to other
hypothetical serine proteases e.g. Rv0983, Rv0125, etc.
Belongs to the serine protease family. Conserved in M.
tuberculosis, M. leprae,M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0983"
/db_xref="EnsemblGenomes-Tr:CCP43733"
/db_xref="GOA:O53896"
/db_xref="InterPro:IPR001478"
/db_xref="InterPro:IPR001940"
/db_xref="InterPro:IPR009003"
/db_xref="InterPro:IPR036034"
/db_xref="PDB:1Y8T"
/db_xref="PDB:2Z9I"
/db_xref="UniProtKB/TrEMBL:O53896"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MAKLARVVGL VQEEQPSDMT NHPRYSPPPQ QPGTPGYAQG QQQTYSQQFD WRYPPSPPPQ
61 PTQYRQPYEA LGGTRPGLIP GVIPTMTPPP GMVRQRPRAG MLAIGAVTIA VVSAGIGGAA
121 ASLVGFNRAP AGPSGGPVAA SAAPSIPAAN MPPGSVEQVA AKVVPSVVML ETDLGRQSEE
181 GSGIILSAEG LILTNNHVIA AAAKPPLGSP PPKTTVTFSD GRTAPFTVVG ADPTSDIAVV
241 RVQGVSGLTP ISLGSSSDLR VGQPVLAIGS PLGLEGTVTT GIVSALNRPV STTGEAGNQN
301 TVLDAIQTDA AINPGNSGGA LVNMNAQLVG VNSAIATLGA DSADAQSGSI GLGFAIPVDQ
361 AKRIADELIS TGKASHASLG VQVTNDKDTL GAKIVEVVAG GAAANAGVPK GVVVTKVDDR
421 PINSADALVA AVRSKAPGAT VALTFQDPSG GSRTVQVTLG KAEQ
//