LOCUS CCP43732.1 504 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Two component sensor
kinase MprB protein.
ACCESSION AL123456-1010
PROTEIN_ID CCP43732.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="mprB"
/locus_tag="Rv0982"
/note="Rv0982, (MTV044.10), len: 504 aa. MprB, two
component sensor kinase, probable transmembrane protein
(see citation below), equivalent to
AL035500|MLCL373_16|NP_301251.1|NC_002677 putative
two-component system sensor kinase from Mycobacterium
leprae (519 aa), FASTA score: (81.0% identity in 521 aa
overlap). Also highly similar to others (especially in
C-terminal part) e.g. AAG36760.1|AF119221_2|AF119221
sensor kinase from Corynebacterium glutamicum (455 aa);
CAB89748.1|AL354616 putative two-component histidine
kinase from Streptomyces coelicolor (481 aa);
X58793|SLCUTRS_2 sensor kinase from S.lividans (414 aa),
FASTA scores: opt: 451, E(): 4.2e-21, (36.0% identity in
303 aa overlap); P30847|BAES_ECOLI sensor protein from
Escherichia coli (467 aa), FASTA scores: opt: 412, E():
1.3e-18, (30.4% identity in 336 aa overlap); etc. Also
similar in C-terminal region to C-terminus of
Rv0902c|Z73101|MTCY31_33 from Mycobacterium tuberculosis
(446 aa), FASTA scores: opt: 423, E(): 2.6e-19, (28.4
identity in 462 aa overlap). MprAB is involved in the
regulation of genes in response to environmental stress
(See He et al., 2006)."
/db_xref="EnsemblGenomes-Gn:Rv0982"
/db_xref="EnsemblGenomes-Tr:CCP43732"
/db_xref="GOA:P9WGL1"
/db_xref="InterPro:IPR003594"
/db_xref="InterPro:IPR003660"
/db_xref="InterPro:IPR003661"
/db_xref="InterPro:IPR004358"
/db_xref="InterPro:IPR005467"
/db_xref="InterPro:IPR036097"
/db_xref="InterPro:IPR036890"
/db_xref="UniProtKB/Swiss-Prot:P9WGL1"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MWWFRRRDRA PLRATSSLSL RWRVMLLAMS MVAMVVVLMS FAVYAVISAA LYSDIDNQLQ
61 SRAQLLIASG SLAADPGKAI EGTAYSDVNA MLVNPGQSIY TAQQPGQTLP VGAAEKAVIR
121 GELFMSRRTT ADQRVLAIRL TNGSSLLISK SLKPTEAVMN KLRWVLLIVG GIGVAVAAVA
181 GGMVTRAGLR PVGRLTEAAE RVARTDDLRP IPVFGSDELA RLTEAFNLML RALAESRERQ
241 ARLVTDAGHE LRTPLTSLRT NVELLMASMA PGAPRLPKQE MVDLRADVLA QIEELSTLVG
301 DLVDLSRGDA GEVVHEPVDM ADVVDRSLER VRRRRNDILF DVEVIGWQVY GDTAGLSRMA
361 LNLMDNAAKW SPPGGHVGVR LSQLDASHAE LVVSDRGPGI PVQERRLVFE RFYRSASARA
421 LPGSGLGLAI VKQVVLNHGG LLRIEDTDPG GQPPGTSIYV LLPGRRMPIP QLPGATAGAR
481 STDIENSRGS ANVISVESQS TRAT
//