LOCUS CCP43722.1 667 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable acetyl-/propionyl-
coenzyme A carboxylase alpha chain (alpha subunit) AccA2:
biotin carboxylase + biotin carboxyl carrier protein (
BCCP) protein.
ACCESSION AL123456-1000
PROTEIN_ID CCP43722.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="accA2"
/gene_synonym="bccA"
/locus_tag="Rv0973c"
/note="Rv0973c, (MTV044.01c, MTCY10D7.01), len: 667 aa.
Probable accA2 (alternate gene name:
bccA),acetyl-/propionyl-coenzyme A carboxylase (alpha
subunit) [includes: biotin carboxylase ; biotin carboxyl
carrier protein (BCCP)], highly similar to others e.g.
CAB95892.1|AL359988 putative acetyl/propionyl CoA
carboxylase alpha subunit from Streptomyces coelicolor
(614 aa); NP_250702.1|NC_002516 probable acyl-CoA
carboxylase alpha chain from Pseudomonas aeruginosa (655
aa); NP_420971.1|NC_002696 acetyl/propionyl-CoA
carboxylase alpha subunit from Caulobacter crescentus (
654 aa); NP_251581.1|NC_002516 probable biotin
carboxylase/biotin carboxyl carrier protein from
Pseudomonas aeruginosa (661 aa); etc. Also highly similar
to others from Mycobacterium tuberculosis e.g.
Rv2501c|P46401|MTCY07A7.07c|BCCA_MYCTU|ACCA1 probable
acetyl-/propionyl-coenzyme A carboxylase alpha chain
(alpha subunit) (654 aa), FASTA scores, opt: 250, E():
4e-09,(28.6% identity in 182 aa overlap); and
Rv3285|MTCY71.25|ACCA3 (600 aa); Z83018|MTCY349_20 (1127
aa), FASTA scores: opt: 838, E(): 0, (40.2% identity in
500 aa overlap). Contains PS00867 Carbamoyl-phosphate
synthase subdomain signature 2 and PS00188
Biotin-requiring enzymes attachment site."
/db_xref="EnsemblGenomes-Gn:Rv0973c"
/db_xref="EnsemblGenomes-Tr:CCP43722"
/db_xref="GOA:P71538"
/db_xref="InterPro:IPR000089"
/db_xref="InterPro:IPR001882"
/db_xref="InterPro:IPR005479"
/db_xref="InterPro:IPR005481"
/db_xref="InterPro:IPR005482"
/db_xref="InterPro:IPR011053"
/db_xref="InterPro:IPR011054"
/db_xref="InterPro:IPR011761"
/db_xref="InterPro:IPR011764"
/db_xref="InterPro:IPR016185"
/db_xref="UniProtKB/TrEMBL:P71538"
/inference="protein motif:PROSITE:PS00188"
/inference="protein motif:PROSITE:PS00867"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MGITRVLVAN RGEIARRVFA TCRRLGLGTV AVYTDPDAAA PHVAEADARV RLPQTTDYLN
61 AEAIIAAAQA AGADAVHPGY GFLSENAEFA AAVQEAGLTW VGPPVDAVRA MGSKIESKKL
121 MAAAGVPVLE ELDPDAVTTA QLPVLVKASA GGGGRGMRVV HELSALPAEV EAARREAQSA
181 FGDPTVFCER YLPTGHHVEV QVMADTHGTV WAVGERECSI QRRHQKIIEE APSPLVERVP
241 GMRAKLFDAA RLAASAIGYT GAGTVEFLAD DSPGREGEFY FLEMNTRLQV EHPVTEETTG
301 LDLVELQLMI ADCGRLDTEP PPAQGYSIEA RLYAEDPAHG WQPQAGVMHT IEVPGVRAQF
361 DSLGQRTGIR LDSGIVDGST VSIHYDPMLA KVVSYGATRR QAALVLADAL VRARLHGLRT
421 NRELLVNVLR HPAFLDGATD TGFFDTHGMA ELSTPLADTA TLRLSAIAAA LADAEHNRAS
481 AGVFSSIPSG WRNLASGYQV KTYRDDADTE HRVEYRFTRT GLALPGDPVV QLVSADVDQV
541 VLAQDGVAHG FTVARHGPDV YVDSARGPVH LVALSRFPEP SSAVEQGSLV APMPGNVIRI
601 GAEVGDTVTA GQPLIWLEAM KMEHTIAAPA DGVLTHVSVN TGQQVEVGAI LARVEAPQNG
661 PAEGDSP
//