LOCUS       CCP43651.1               236 aa    PRT              BCT 27-FEB-2015
DEFINITION  Mycobacterium tuberculosis H37Rv Two component response
            transcriptional regulatory protein PrrA protein.
ACCESSION   AL123456-929
PROTEIN_ID  CCP43651.1
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
            Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
            Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
            Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
            Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
            Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
            Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
            Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
            Barrell B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393(6685), 537-544(1998).
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   2
  AUTHORS   Camus J.C., Pryor M.J., Medigue C., Cole S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
   PUBMED   12368430
REFERENCE   3
  AUTHORS   Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
  TITLE     TubercuList--10 years after
  JOURNAL   Tuberculosis (Edinb) 91(1), 1-7(2011).
   PUBMED   20980199
REFERENCE   4  (bases 1 to 4411529)
  AUTHORS   Parkhill J.
  JOURNAL   Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
            Mycobacterium tuberculosis sequencing and mapping teams, Sanger
            Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
            Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
            rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
            parkhill@sanger.ac.uk
REFERENCE   5  (bases 1 to 4411532)
  AUTHORS   Lew J.M.
  JOURNAL   Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
            Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
            Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
            4, SWITZERLAND
COMMENT     On or before Feb 1, 2013 this sequence version replaced
            gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
            gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
            gi:38490319, gi:41352785, gi:38490370, gi:41353971.
            Note:
            This annotation is from the TubercuList website, Release 26, Dec
            2012 (URL: http://tuberculist.epfl.ch) (email:
            tuberculist@epfl.ch).
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37Rv"
                     /strain="H37Rv"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:83332"
     protein         /transl_table=11
                     /gene="prrA"
                     /locus_tag="Rv0903c"
                     /note="Rv0903c, (MTCY31.31c), len: 236 aa.
                     PrrA,two-component response regulator (see citations
                     below),equivalent to
                     Z99494|MLCB57_27|NP_302402.1|NC_002677 two-component
                     response regulator from Mycobacterium leprae (233 aa),
                     FASTA scores: opt: 1414, E(): 0, (95.7% identity in 233 aa
                     overlap); and similar to T45446 probable two-component
                     response regulator from Mycobacterium leprae (253 aa).
                     Also similar to many sensor-like histidine kinase proteins
                     e.g. CAB88489.1|AL353816 putative two-component systen
                     response regulator from Streptomyces coelicolor (248 aa);
                     AAG36759.1|AF119221_1 |AF119221 response regulator from
                     Corynebacterium glutamicum (232 aa); Q02540|COPR_PSESM
                     transcriptional activator protein COPR from Pseudomonas
                     syringae (pv. tomato) (227 aa), FASTA scores: opt:
                     600,E(): 0, (44.4% identity in 225 aa overlap); etc. Also
                     similar to Rv0981 from Mycobacterium tuberculosis (230
                     aa),Rv3765c (234 aa), phoP (247 aa), etc. Thought to be
                     induced at phagocytosis (see Graham & Clark-Curtiss
                     1999)."
                     /db_xref="EnsemblGenomes-Gn:Rv0903c"
                     /db_xref="EnsemblGenomes-Tr:CCP43651"
                     /db_xref="GOA:P9WGM1"
                     /db_xref="InterPro:IPR001789"
                     /db_xref="InterPro:IPR001867"
                     /db_xref="InterPro:IPR011006"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR039420"
                     /db_xref="PDB:1YS6"
                     /db_xref="PDB:1YS7"
                     /db_xref="UniProtKB/Swiss-Prot:P9WGM1"
                     /experiment="EXISTENCE: identified in proteomics study"
BEGIN
        1 MGGMDTGVTS PRVLVVDDDS DVLASLERGL RLSGFEVATA VDGAEALRSA TENRPDAIVL
       61 DINMPVLDGV SVVTALRAMD NDVPVCVLSA RSSVDDRVAG LEAGADDYLV KPFVLAELVA
      121 RVKALLRRRG STATSSSETI TVGPLEVDIP GRRARVNGVD VDLTKREFDL LAVLAEHKTA
      181 VLSRAQLLEL VWGYDFAADT NVVDVFIGYL RRKLEAGGGP RLLHTVRGVG FVLRMQ
//