LOCUS CCP43647.1 326 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Outer membrane protein
A OmpA protein.
ACCESSION AL123456-925
PROTEIN_ID CCP43647.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="ompA"
/gene_synonym="ompATb"
/locus_tag="Rv0899"
/note="Rv0899, (MTCY31.27), len: 326 aa. OmpA, outer
membrane protein A (See Senaratne et al., 1998).
C-terminal region similar to C-terminus of many members of
the OmpA family of outer membrane proteins, e.g.
NP_458280.1|NC_003198 putative outer membrane protein from
Salmonella enterica subsp. enterica serovar Typhi (220);
NP_418008.1|NC_000913 putative outer membrane protein from
Escherichia coli strain K12 (219 aa), FASTA scores: opt:
296, E(): 2.2e-11, (45.3% identity in 117 aa overlap);
NP_231844.1|NC_002505 outer membrane protein OmpA from
Vibrio cholerae (321 aa); Q05146|OMPA_BORAV outer membrane
protein A precursor from Bordetella avium (194 aa); etc. A
signal peptide sequence probably exists at the N-terminus.
N-terminal domain is necessary and sufficient for membrane
translocation (See Alahari et al., 2007). Contains PS00044
Bacterial regulatory proteins, lysR family signature.
Belongs to the OmpA family. Pore-forming activity is
pH-dependent."
/db_xref="EnsemblGenomes-Gn:Rv0899"
/db_xref="EnsemblGenomes-Tr:CCP43647"
/db_xref="GOA:P9WIU5"
/db_xref="InterPro:IPR006664"
/db_xref="InterPro:IPR006665"
/db_xref="InterPro:IPR006690"
/db_xref="InterPro:IPR007055"
/db_xref="InterPro:IPR036737"
/db_xref="PDB:2KGS"
/db_xref="PDB:2KGW"
/db_xref="PDB:2KSM"
/db_xref="PDB:2L26"
/db_xref="PDB:2LBT"
/db_xref="PDB:2LCA"
/db_xref="UniProtKB/Swiss-Prot:P9WIU5"
/inference="protein motif:PROSITE:PS00044"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MASKAGLGQT PATTDARRTQ KFYRGSPGRP WLIGAVVIPL LIAAIGYGAF ERPQSVTGPT
61 GVLPTLTPTS TRGASALSLS LLSISRSGNT VTLIGDFPDE AAKAALMTAL NGLLAPGVNV
121 IDQIHVDPVV RSLDFSSAEP VFTASVPIPD FGLKVERDTV TLTGTAPSSE HKDAVKRAAT
181 STWPDMKIVN NIEVTGQAPP GPPASGPCAD LQSAINAVTG GPIAFGNDGA SLIPADYEIL
241 NRVADKLKAC PDARVTINGY TDNTGSEGIN IPLSAQRAKI VADYLVARGV AGDHIATVGL
301 GSVNPIASNA TPEGRAKNRR VEIVVN
//