LOCUS CCP43412.1 637 aa PRT BCT 27-FEB-2015 DEFINITION Mycobacterium tuberculosis H37Rv Possible hydrolase protein. ACCESSION AL123456-690 PROTEIN_ID CCP43412.1 SOURCE Mycobacterium tuberculosis H37Rv ORGANISM Mycobacterium tuberculosis H37Rv Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J., Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. TITLE Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence JOURNAL Nature 393(6685), 537-544(1998). PUBMED 9634230 REMARK Erratum:[Nature 1998 Nov 12;396(6707):190] REFERENCE 2 AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T. TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002). PUBMED 12368430 REFERENCE 3 AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. TITLE TubercuList--10 years after JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011). PUBMED 20980199 REFERENCE 4 (bases 1 to 4411529) AUTHORS Parkhill J. JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the Mycobacterium tuberculosis sequencing and mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: parkhill@sanger.ac.uk REFERENCE 5 (bases 1 to 4411532) AUTHORS Lew J.M. JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva 4, SWITZERLAND COMMENT On or before Feb 1, 2013 this sequence version replaced gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250, gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756, gi:38490319, gi:41352785, gi:38490370, gi:41353971. Note: This annotation is from the TubercuList website, Release 26, Dec 2012 (URL: http://tuberculist.epfl.ch) (email: tuberculist@epfl.ch). FEATURES Qualifiers source /organism="Mycobacterium tuberculosis H37Rv" /strain="H37Rv" /mol_type="genomic DNA" /db_xref="taxon:83332" protein /transl_table=11 /locus_tag="Rv0669c" /note="Rv0669c, (MTCI376.05), len: 637 aa. Possible hydrolase, highly similar to various hydrolases (N-terminus shorter) e.g. BAA88409.1|AB028646 alkaline ceramidase from Pseudomonas aeruginosa (670 aa,) FASTA scores: opt: 1490,E(): 0, (41.2% identity in 651 aa overlap); NP_063946.1|NM_019893 mitochondrial ceramidase from Homo sapiens (761 aa); P_446098.1|NM_053646 N-acylsphingosine amidohydrolase 2 from Rattus norvegicus (761 aa); BAB09641.1|AB016885 neutral ceramidase from Arabidopsis thaliana (705 aa); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop)." /db_xref="EnsemblGenomes-Gn:Rv0669c" /db_xref="EnsemblGenomes-Tr:CCP43412" /db_xref="GOA:O06769" /db_xref="InterPro:IPR006823" /db_xref="InterPro:IPR031329" /db_xref="InterPro:IPR031331" /db_xref="InterPro:IPR038445" /db_xref="UniProtKB/Swiss-Prot:O06769" /inference="protein motif:PROSITE:PS00017" /experiment="EXISTENCE: identified in proteomics study" BEGIN 1 MLSVGRGIAD ITGEAADCGM LGYGKSDQRT AGIHQRLRSR AFVFRDDSQD GDARLLLIVA 61 ELPLPMQNVN EEVLRRLADL YGDTYSEQNT LITATHTHAG PGGYCGYLLY NLTTSGFRPA 121 TFAAIVDGIV ESVEHAHADV APAEVSLSHG ELYGASINRS PSAFDRNPPA DKAFFPKRVD 181 PHTTLVRIDR GEATVGVIHF FATHGTSMTN RNHLISGDNK GFAAYHWERT VGGADYLAGQ 241 PDFIAAFAQT NPGDMSPNVD GPLSPEAPPD REFDNTRRTG LCQFEDAFTQ LSGATPIGAG 301 IDARFTYVDL GSVLVRGEYT PDGEERRTGR PMFGAGAMAG TDEGPGFHGF RQGRNPFWDR 361 LSRAMYRLAR PTAAAQAPKG IVMPARLPNR IHPFVQEIVP VQLVRIGRLY LIGIPGEPTI 421 VAGLRLRRMV ASIVGADLAD VLCVGYTNAY IHYVTTPEEY LEQRYEGGST LFGRWELCAL 481 MQTVAELAEA MRDGRPVTLG RRPRPTRELS WVRGAPADAG SFGAVIAEPS ATYRPGQAVE 541 AVFVSALPNN DLRRGGTYLE VVRREGASWV RIADDGDWAT SFRWQRQGRA GSHVSIRWDV 601 PGDTTPGQYR IVHHGTARDR NGMLTAFSAT TREFTVV //