LOCUS CCP43370.1 575 aa PRT BCT 27-FEB-2015 DEFINITION Mycobacterium tuberculosis H37Rv Probable exonuclease V (alpha chain) RecD (exodeoxyribonuclease V alpha chain) (exodeoxyribonuclease V polypeptide) protein. ACCESSION AL123456-648 PROTEIN_ID CCP43370.1 SOURCE Mycobacterium tuberculosis H37Rv ORGANISM Mycobacterium tuberculosis H37Rv Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J., Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. TITLE Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence JOURNAL Nature 393(6685), 537-544(1998). PUBMED 9634230 REMARK Erratum:[Nature 1998 Nov 12;396(6707):190] REFERENCE 2 AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T. TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002). PUBMED 12368430 REFERENCE 3 AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. TITLE TubercuList--10 years after JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011). PUBMED 20980199 REFERENCE 4 (bases 1 to 4411529) AUTHORS Parkhill J. JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the Mycobacterium tuberculosis sequencing and mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: parkhill@sanger.ac.uk REFERENCE 5 (bases 1 to 4411532) AUTHORS Lew J.M. JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva 4, SWITZERLAND COMMENT On or before Feb 1, 2013 this sequence version replaced gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250, gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756, gi:38490319, gi:41352785, gi:38490370, gi:41353971. Note: This annotation is from the TubercuList website, Release 26, Dec 2012 (URL: http://tuberculist.epfl.ch) (email: tuberculist@epfl.ch). FEATURES Qualifiers source /organism="Mycobacterium tuberculosis H37Rv" /strain="H37Rv" /mol_type="genomic DNA" /db_xref="taxon:83332" protein /transl_table=11 /gene="recD" /locus_tag="Rv0629c" /note="Rv0629c, (MTCY20H10.10c), len: 575 aa. Probable recD, exonuclease V, alpha chain (exodeoxyribonuclease V,alpha chain) (see citation below), highly similar to other exonucleases e.g. AF157643_3|AAD46809.1|recD Escherichia coli RecD protein homolog from Mycobacterium smegmatis (554 aa); P04993|EX5A_ECOLI|B2819 exodeoxyribonuclease V 67kd polypeptide (exonuclease V alpha chain) from Escherichia coli strain K12 (608 aa), FASTA scores: opt: 512, E(): 1.9e-24, (36.9% identity in 582 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Consists of three subunits; RECB|Rv0630c, RECC|Rv0631c and RECD." /db_xref="EnsemblGenomes-Gn:Rv0629c" /db_xref="EnsemblGenomes-Tr:CCP43370" /db_xref="GOA:P9WHJ1" /db_xref="InterPro:IPR006344" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="UniProtKB/Swiss-Prot:P9WHJ1" /inference="protein motif:PROSITE:PS00017" /experiment="EXISTENCE: identified in proteomics study" BEGIN 1 MKLTDVDFAV EASGMVRAFN QAGVLDVSDV HVAQRLCALA GESDERVALA VAVAVRALRA 61 GSVCVDLLSI ARVAGHDDLP WPDPADWLAA VRASPLLADP PVLHLYDDRL LYLDRYWREE 121 EQVCADLLAL LTSRRPAGVP DLRRLFPTGF DEQRRAAEIA LSQGVTVLTG GPGTGKTTTV 181 ARLLALVAEQ AELAGEPRPR IALAAPTGKA AARLAEAVRR EMAKLDATDR ARLGDLHAVT 241 LHRLLGAKPG ARFRQDRQNR LPHNVIVVDE TSMVSLTLMA RLAEAVRPGA RLILVGDADQ 301 LASVEAGAVL ADLVDGFSVR DDALVAQLRT SHRFGKVIGT LAEAIRAGDG DAVLGLLRSG 361 EERIEFVDDE DPAPRLRAVL VPHALRLREA ALLGASDVAL ATLDEHRLLC AHRDGPTGVL 421 HWNRRVQAWL AEETGQPPWT PWYAGRPLLV TANDYGLRVY NGDTGVVLAG PTGLRAVISG 481 ASGPLDVATG RLGDVETMHA MTIHKSQGSQ VDEVTVLMPQ EDSRLLTREL LYTAVTRAKR 541 KVRVVGSEAS VRAAIARRAV RASGLRMRLQ STGCG //