LOCUS CCP43249.1 329 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable delta-aminolevulinic
acid dehydratase HemB (porphobilinogen synthase) (ALAD)
(ALADH) protein.
ACCESSION AL123456-527
PROTEIN_ID CCP43249.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="hemB"
/locus_tag="Rv0512"
/note="Rv0512, (MTCY20G10.02), len: 329 aa. Probable
hemB,delta-aminolevulinic acid dehydratase, equivalent to
46723|HEM2_MYCLE delta-aminolevulinic acid dehydratase
from Mycobacterium leprae (329 aa). Also highly similar to
many e.g. P54919|HEM2_STRCO from Streptomyces coelicolor
(330 aa); HEM2_ECOLI|P15002 from Escherichia coli (323
aa),FASTA scores: opt: 942, E(): 0, (47.6% identity in 317
aa overlap); etc. Contains PS00169 Delta-aminolevulinic
acid dehydratase active site. Belongs to the ALADH family.
Cofactor: zinc."
/db_xref="EnsemblGenomes-Gn:Rv0512"
/db_xref="EnsemblGenomes-Tr:CCP43249"
/db_xref="GOA:P9WMP5"
/db_xref="InterPro:IPR001731"
/db_xref="InterPro:IPR013785"
/db_xref="InterPro:IPR030656"
/db_xref="UniProtKB/Swiss-Prot:P9WMP5"
/inference="protein motif:PROSITE:PS00169"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MSMSSYPRQR PRRLRSTVAM RRLVAQTSLE PRHLVLPMFV ADGIDEPRPI TSMPGVVQHT
61 RDSLRRAAAA AVAAGVGGLM LFGVPRDQDK DGVGSAGIDP DGILNVALRD LAKDLGEATV
121 LMADTCLDEF TDHGHCGVLD DRGRVDNDAT VARYVELAVA QAESGAHVVG PSGMMDGQVA
181 AIRDGLDAAG YIDVVILAYA AKFASAFYGP FREAVSSSLS GDRRTYQQEP GNAAEALREI
241 ELDLDEGADI VMVKPAMGYL DVVAAAADVS PVPVAAYQVS GEYAMIRAAA ANNWIDERAA
301 VLESLTGIRR AGADIVLTYW AVDAAGWLT
//