LOCUS       CCP43106.1               380 aa    PRT              BCT 27-FEB-2015
DEFINITION  Mycobacterium tuberculosis H37Rv Conserved hypothetical
            protein protein.
ACCESSION   AL123456-384
PROTEIN_ID  CCP43106.1
SOURCE      Mycobacterium tuberculosis H37Rv
  ORGANISM  Mycobacterium tuberculosis H37Rv
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
            Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
            Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
            Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
            Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
            Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
            Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
            Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
            Barrell B.G.
  TITLE     Deciphering the biology of Mycobacterium tuberculosis from the
            complete genome sequence
  JOURNAL   Nature 393(6685), 537-544(1998).
   PUBMED   9634230
  REMARK    Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE   2
  AUTHORS   Camus J.C., Pryor M.J., Medigue C., Cole S.T.
  TITLE     Re-annotation of the genome sequence of Mycobacterium tuberculosis
            H37Rv
  JOURNAL   Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
   PUBMED   12368430
REFERENCE   3
  AUTHORS   Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
  TITLE     TubercuList--10 years after
  JOURNAL   Tuberculosis (Edinb) 91(1), 1-7(2011).
   PUBMED   20980199
REFERENCE   4  (bases 1 to 4411529)
  AUTHORS   Parkhill J.
  JOURNAL   Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
            Mycobacterium tuberculosis sequencing and mapping teams, Sanger
            Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
            Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
            rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
            parkhill@sanger.ac.uk
REFERENCE   5  (bases 1 to 4411532)
  AUTHORS   Lew J.M.
  JOURNAL   Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
            Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
            Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
            4, SWITZERLAND
COMMENT     On or before Feb 1, 2013 this sequence version replaced
            gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
            gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
            gi:38490319, gi:41352785, gi:38490370, gi:41353971.
            Note:
            This annotation is from the TubercuList website, Release 26, Dec
            2012 (URL: http://tuberculist.epfl.ch) (email:
            tuberculist@epfl.ch).
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis H37Rv"
                     /strain="H37Rv"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:83332"
     protein         /transl_table=11
                     /locus_tag="Rv0376c"
                     /note="Rv0376c, (MTV036.11c), len: 380 aa. Conserved
                     hypothetical protein, highly similar to
                     T35481|4008539|CAA22508.1|AL034492|SC6C5.10 hypothetical
                     protein from Streptomyces coelicolor (395 aa); and
                     AAK64260.1|AF373840_20 ORF377 hypothetical CoxI from
                     Arthrobacter nicotinovorans (377 aa). And similar to other
                     conserved hypothetical proteins e.g.
                     NP_101963.1|14021136|BAB47749.1|AP002994 hypothetical
                     protein from Mesorhizobium loti (245 aa). Note that
                     C-terminus shows similarity with C-termini of
                     CAB76248.1|X82447|COXF CoxF protein from
                     Pseudomonas/Oligotropha carboxidovorans (280 aa);
                     CAB76250.1|X82447|COXI CoxI protein from
                     Pseudomonas/Oligotropha carboxidovorans (330 aa); and
                     AJ224684|BJAJ4684_6 cooxS from Bradyrhizobium japonicum
                     (176 aa), FASTA scores: E(): 1.9e-17, (47.1% identity in
                     138 aa overlap). Also some partial similarity with
                     AJ224684|BJAJ4684_5 cooxS from Bradyrhizobium japonicum
                     (107 aa), FASTA scores: opt: 321, E(): 4.2e-14, (53.3%
                     identity in 92 aa overlap); E1184330|Z99120|YURF YURF
                     protein from Bacillus subtilis (330 aa), FASTA scores:
                     opt: 170, E(): 2.9e- 16, (27.5% identity in 345 aa
                     overlap). Also similar to downstream ORF Rv0372c from
                     Mycobacterium tuberculosis (251 aa), FASTA scores: E():
                     2.1e-06, (30.7% identity in 277 aa overlap)."
                     /db_xref="EnsemblGenomes-Gn:Rv0376c"
                     /db_xref="EnsemblGenomes-Tr:CCP43106"
                     /db_xref="InterPro:IPR003777"
                     /db_xref="InterPro:IPR027051"
                     /db_xref="UniProtKB/TrEMBL:O53711"
                     /experiment="EXISTENCE: identified in proteomics study"
BEGIN
        1 MAIWAAGDTA GVATVVRTLR SAPRPPGAAM VVAPDGSVSG SVSGGCVEGA VYELAAEVAQ
       61 TGIPRLEHYG VSDDTAFAVG LTCGGIIDVF VEPVSRATFP ELGELADDIG AQRPVAIATV
      121 IAHPDERRVG RRLVIRPDTK SPVTGSLGSA RADAAVIDDA RGLLAVGRSE ILEYGPDGQR
      181 RGEGMEVFVS SHAPRPRMLV FGAIDFAAAL ARQGSFLGYR VTVCDARAVF ATPARFPTAD
      241 DVVVAWPHRY LAAQAEAGGI DERTVICVLT HDPKFDVPVL EVALRLGVGY VGAMGSRKTH
      301 DDRMDRLRAA GLTDAELSRL SSPIGLDLGA RTPEETAVSI AADIIARRWG GGGRPLADIA
      361 GRIHHDAQVA GEFKDYLTRH
//