LOCUS CCP43021.1 461 aa PRT BCT 27-FEB-2015
DEFINITION Mycobacterium tuberculosis H37Rv Probable membrane-anchored
mycosin MycP3 (serine protease) (subtilisin-like protease)
(subtilase-like) (mycosin-3) protein.
ACCESSION AL123456-299
PROTEIN_ID CCP43021.1
SOURCE Mycobacterium tuberculosis H37Rv
ORGANISM Mycobacterium tuberculosis H37Rv
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.,
Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III.,
Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
Connor R., Davies R., Devlin K., Feltwell T., Gentles S.,
Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J.,
Moule S., Murphy L., Oliver K., Osborne J., Quail M.A.,
Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J.,
Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S.,
Barrell B.G.
TITLE Deciphering the biology of Mycobacterium tuberculosis from the
complete genome sequence
JOURNAL Nature 393(6685), 537-544(1998).
PUBMED 9634230
REMARK Erratum:[Nature 1998 Nov 12;396(6707):190]
REFERENCE 2
AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T.
TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis
H37Rv
JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002).
PUBMED 12368430
REFERENCE 3
AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T.
TITLE TubercuList--10 years after
JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011).
PUBMED 20980199
REFERENCE 4 (bases 1 to 4411529)
AUTHORS Parkhill J.
JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the
Mycobacterium tuberculosis sequencing and mapping teams, Sanger
Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA
Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28
rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail:
parkhill@sanger.ac.uk
REFERENCE 5 (bases 1 to 4411532)
AUTHORS Lew J.M.
JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique
Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss
Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva
4, SWITZERLAND
COMMENT On or before Feb 1, 2013 this sequence version replaced
gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250,
gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756,
gi:38490319, gi:41352785, gi:38490370, gi:41353971.
Note:
This annotation is from the TubercuList website, Release 26, Dec
2012 (URL: http://tuberculist.epfl.ch) (email:
tuberculist@epfl.ch).
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis H37Rv"
/strain="H37Rv"
/mol_type="genomic DNA"
/db_xref="taxon:83332"
protein /transl_table=11
/gene="mycP3"
/locus_tag="Rv0291"
/note="Rv0291, (MTV035.19), len: 461 aa. Probable
mycP3,membrane-anchored serine protease (mycosin) (see
Brown et al., 2000), similar to several others in
mycobacteria e.g. Z94121|MTY15F10_28|Rv1796 from
Mycobacterium tuberculosis (446 aa), FASTA scores: opt:
1168, E(): 0, (44.6% identity in 453 aa overlap); Rv3886c;
Rv3883c; Rv3449; and Y14967|MLCB628_4|MLCB628.04 from
Mycobacterium leprae (446 aa), FASTA scores: opt: 1159,
E(): 0, (43.5 identity in 446 aa overlap). Has signal
sequence and hydrophobic stretch at C-terminus, followed
by short positively charged segment,that seems to act as a
membrane anchor. Contains PS00137 Serine proteases,
subtilase family, histidine active site signature. Belongs
to peptidase family S8 (also known as the subtilase
family), pyrolysin subfamily. Conserved in M.
tuberculosis, M. leprae, M. bovis and M. avium
paratuberculosis; predicted to be essential for in vivo
survival and pathogenicity (See Ribeiro-Guimaraes and
Pessolani, 2007)."
/db_xref="EnsemblGenomes-Gn:Rv0291"
/db_xref="EnsemblGenomes-Tr:CCP43021"
/db_xref="GOA:O53695"
/db_xref="InterPro:IPR000209"
/db_xref="InterPro:IPR015500"
/db_xref="InterPro:IPR022398"
/db_xref="InterPro:IPR023834"
/db_xref="InterPro:IPR036852"
/db_xref="UniProtKB/Swiss-Prot:O53695"
/inference="protein motif:PROSITE:PS00137"
/experiment="EXISTENCE: identified in proteomics study"
BEGIN
1 MIRAAFACLA ATVVVAGWWT PPAWAIGPPV VDAAAQPPSG DPGPVAPMEQ RGACSVSGVI
61 PGTDPGVPTP SQTMLNLPAA WQFSRGEGQL VAIIDTGVQP GPRLPNVDAG GDFVESTDGL
121 TDCDGHGTLV AGIVAGQPGN DGFSGVAPAA RLLSIRAMST KFSPRTSGGD PQLAQATLDV
181 AVLAGAIVHA ADLGAKVINV STITCLPADR MVDQAALGAA IRYAAVDKDA VIVAAAGNTG
241 ASGSVSASCD SNPLTDLSRP DDPRNWAGVT SVSIPSWWQP YVLSVASLTS AGQPSKFSMP
301 GPWVGIAAPG ENIASVSNSG DGALANGLPD AHQKLVALSG TSYAAGYVSG VAALVRSRYP
361 GLNATEVVRR LTATAHRGAR ESSNIVGAGN LDAVAALTWQ LPAEPGGGAA PAKPVADPPV
421 PAPKDTTPRN VAFAGAAALS VLVGLTAATV AIARRRREPT E
//