LOCUS CCP42772.1 678 aa PRT BCT 27-FEB-2015 DEFINITION Mycobacterium tuberculosis H37Rv Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase (peptidoglycan TGASE) + penicillin-sensitive transpeptidase (DD-transpeptidase) protein. ACCESSION AL123456-50 PROTEIN_ID CCP42772.1 SOURCE Mycobacterium tuberculosis H37Rv ORGANISM Mycobacterium tuberculosis H37Rv Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., Gordon S.V., Eiglmeier K., Gas S., Barry C.E.III., Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L., Oliver K., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton J., Squares R., Squares S., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. TITLE Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence JOURNAL Nature 393(6685), 537-544(1998). PUBMED 9634230 REMARK Erratum:[Nature 1998 Nov 12;396(6707):190] REFERENCE 2 AUTHORS Camus J.C., Pryor M.J., Medigue C., Cole S.T. TITLE Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv JOURNAL Microbiology (Reading, Engl.) 148(Pt 10), 2967-2973(2002). PUBMED 12368430 REFERENCE 3 AUTHORS Lew J.M., Kapopoulou A., Jones L.M., Cole S.T. TITLE TubercuList--10 years after JOURNAL Tuberculosis (Edinb) 91(1), 1-7(2011). PUBMED 20980199 REFERENCE 4 (bases 1 to 4411529) AUTHORS Parkhill J. JOURNAL Submitted (11-JUN-1998) to the INSDC. Submitted on behalf of the Mycobacterium tuberculosis sequencing and mapping teams, Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA Unite de Genetique Moleculaire Bacterienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France E-mail: parkhill@sanger.ac.uk REFERENCE 5 (bases 1 to 4411532) AUTHORS Lew J.M. JOURNAL Submitted (18-DEC-2012) to the INSDC. Lew J., Ecole Polytechnique Federale de Lausanne, CH-1015, Lausanne, Switzerland, and the Swiss Institute of Bioinformatics, CMU - Rue Michel-Servet 1, 1211 Geneva 4, SWITZERLAND COMMENT On or before Feb 1, 2013 this sequence version replaced gi:41352722, gi:38490165, gi:38490207, gi:41353619, gi:38490250, gi:38684030, gi:38490288, gi:41353667, gi:41353422, gi:41352756, gi:38490319, gi:41352785, gi:38490370, gi:41353971. Note: This annotation is from the TubercuList website, Release 26, Dec 2012 (URL: http://tuberculist.epfl.ch) (email: tuberculist@epfl.ch). FEATURES Qualifiers source /organism="Mycobacterium tuberculosis H37Rv" /strain="H37Rv" /mol_type="genomic DNA" /db_xref="taxon:83332" protein /transl_table=11 /gene="ponA1" /locus_tag="Rv0050" /note="Rv0050, (MTCY21D4.13), len: 678 aa. Probable ponA1,penicillin-binding protein (class A), bienzymatic protein with transglycosylase and transpeptidase activities (see Graham & Clark-Curtiss 1999), highly similar to many (see Billman-Jacobe et al., 1999). Belongs to the transglycosylase family in the N-terminal section, and to the transpeptidase family in the C-terminal section." /db_xref="EnsemblGenomes-Gn:Rv0050" /db_xref="EnsemblGenomes-Tr:CCP42772" /db_xref="GOA:P71707" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="PDB:5CRF" /db_xref="PDB:5CXW" /db_xref="UniProtKB/Swiss-Prot:P71707" /experiment="EXISTENCE: identified in proteomics study" BEGIN 1 MVILLPMVTF TMAYLIVDVP KPGDIRTNQV STILASDGSE IAKIVPPEGN RVDVNLSQVP 61 MHVRQAVIAA EDRNFYSNPG FSFTGFARAV KNNLFGGDLQ GGSTITQQYV KNALVGSAQH 121 GWSGLMRKAK ELVIATKMSG EWSKDDVLQA YLNIIYFGRG AYGISAASKA YFDKPVEQLT 181 VAEGALLAAL IRRPSTLDPA VDPEGAHARW NWVLDGMVET KALSPNDRAA QVFPETVPPD 241 LARAENQTKG PNGLIERQVT RELLELFNID EQTLNTQGLV VTTTIDPQAQ RAAEKAVAKY 301 LDGQDPDMRA AVVSIDPHNG AVRAYYGGDN ANGFDFAQAG LQTGSSFKVF ALVAALEQGI 361 GLGYQVDSSP LTVDGIKITN VEGEGCGTCN IAEALKMSLN TSYYRLMLKL NGGPQAVADA 421 AHQAGIASSF PGVAHTLSED GKGGPPNNGI VLGQYQTRVI DMASAYATLA ASGIYHPPHF 481 VQKVVSANGQ VLFDASTADN TGDQRIPKAV ADNVTAAMEP IAGYSRGHNL AGGRDSAAKT 541 GTTQFGDTTA NKDAWMVGYT PSLSTAVWVG TVKGDEPLVT ASGAAIYGSG LPSDIWKATM 601 DGALKGTSNE TFPKPTEVGG YAGVPPPPPP PEVPPSETVI QPTVEIAPGI TIPIGPPTTI 661 TLAPPPPAPP AATPTPPP //