LOCUS       CAB5248316.1             478 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 MCE-
            FAMILY PROTEIN MCE2DA [FIRST PART] protein.
ACCESSION   LT708304-615
PROTEIN_ID  CAB5248316.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mce2Da"
                     /locus_tag="BQ2027_MB0607"
                     /note="Mb0607, mce2Da, len: 478 aa. Equivalent to 5' end
                     of Rv0592, len: 508 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.2% identity in 471 aa overlap). mce2D;
                     belongs to 24-membered Mycobacterium tuberculosis Mce
                     protein family (see citations below for more information),
                     highly similar to Mycobacterium tuberculosis proteins
                     O07416|Rv0172|MTCI28.12|mce1D (530 aa);
                     O53970|Rv1969|MTV051.07|mce3D (423 aa); etc. Also highly
                     similar to others e.g. NP_302659.1|NC_002677 putative
                     secreted protein from Mycobacterium leprae (531 aa);
                     CAC12795.1|AL445327 putative secreted protein from
                     Streptomyces coelicolor (337 aa); etc. Has highly Pro-rich
                     C-terminus and may contain N-terminal signal or anchor
                     sequence. REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, mce2D exists as a single gene.
                     In Mycobacterium bovis, a frameshift due to a single base
                     insertion (*-c) splits mce2D into 2 parts, mce2Da and
                     mce2Db. Mb0607 found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing (TPM >
                     20)."
BEGIN
        1 MSTIFDIRSL RLPKLSAKVV VVGGLVVVLA VVAAAAGARL YRKLTTTTVV AYFSEALALY
       61 PGDKVQIMGV RVGSIDKIEP AGDKMRVTLH YSNKYQVPAT ATASILNPSL VASRTIQLSP
      121 PYTGGPVLQD GAVIPIERTQ VPVEWDQLRD SINGILRQLG PTERQPKGPF GDLIESAADN
      181 LAGKGRQLNE TLNSLSQALT ALNEGRGDFV AITRSLALFV SALYQNDQQF VALNENLAEF
      241 TDWFTKSDHD LADTVERIDD VLGTVRKFVS DNRSVLAADV NNLADATTTL VQPEPRDGLE
      301 TALHVLPTYA SNFNNLYYPL HSSLVGQFVF PNFANPIQLI CSAIQAGSRL GYQESAELCA
      361 QYLAPVLDAL KFNYLPFGSN PFSSAATLPK EVAYSEERLR PPPGYKDTTV PGIFSRDTPF
      421 SHGNHEPGWV VAPGMQGMQV QPFTANMLTP ESLAELLGGP DIAPPAAGNQ LARTAECV
//