LOCUS       CAB5248310.1             240 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            transcriptional regulatory protein mce2r (gntr-family)
            protein.
ACCESSION   LT708304-609
PROTEIN_ID  CAB5248310.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mce2r"
                     /locus_tag="BQ2027_MB0601"
                     /note="Mb0601, -, len: 240 aa. Equivalent to Rv0586, len:
                     240 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 240 aa overlap). Probable
                     transcriptional regulator, GntR family, similar to many
                     e.g. P33233|LLDR_ECOLI putative L-lactate dehydrogenase
                     operon regulatory protein from Escherichia coli (258 aa),
                     FASTA scores: opt: 225, E(): 9.3e-08, (26.7% identity in
                     232 aa overlap); etc. Also similar to other M.
                     tuberculosis transcriptional regulators GntR proteins e.g.
                     Rv3060c, Rv0792c, etc. Contains PS00043 Bacterial
                     regulatory proteins, gntR family signature and probable
                     helix-turn helix motif from aa 35-56 (Score 1531, +4.40
                     SD). Protein product from Mb0601 detected using SWATH mass
                     spectrometry. Mb0601 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MALQPVTRRS VPEEVFEQIA TDVLTGEMPP GEALPSERRL AELLGVSRPA VREALKRLSA
       61 AGLVEVRQGD VTTVRDFRRH AGLDLLPRLL FRNGELDISV VRSILEARLR NFPKVAELAA
      121 ERNEPELAEL LQDSLRALDT EEDPIVWQRH TLDFWDHVVD SAGSIVDRLM YNAFRAAYEP
      181 TLAALTTTMT AAAKRPSDYR KLADAICSGD PTGAKKAAQD LLELANTSLM AVLVSQASRQ
//