LOCUS CAB5248310.1 240 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable transcriptional regulatory protein mce2r (gntr-family) protein. ACCESSION LT708304-609 PROTEIN_ID CAB5248310.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="mce2r" /locus_tag="BQ2027_MB0601" /note="Mb0601, -, len: 240 aa. Equivalent to Rv0586, len: 240 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 240 aa overlap). Probable transcriptional regulator, GntR family, similar to many e.g. P33233|LLDR_ECOLI putative L-lactate dehydrogenase operon regulatory protein from Escherichia coli (258 aa), FASTA scores: opt: 225, E(): 9.3e-08, (26.7% identity in 232 aa overlap); etc. Also similar to other M. tuberculosis transcriptional regulators GntR proteins e.g. Rv3060c, Rv0792c, etc. Contains PS00043 Bacterial regulatory proteins, gntR family signature and probable helix-turn helix motif from aa 35-56 (Score 1531, +4.40 SD). Protein product from Mb0601 detected using SWATH mass spectrometry. Mb0601 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." BEGIN 1 MALQPVTRRS VPEEVFEQIA TDVLTGEMPP GEALPSERRL AELLGVSRPA VREALKRLSA 61 AGLVEVRQGD VTTVRDFRRH AGLDLLPRLL FRNGELDISV VRSILEARLR NFPKVAELAA 121 ERNEPELAEL LQDSLRALDT EEDPIVWQRH TLDFWDHVVD SAGSIVDRLM YNAFRAAYEP 181 TLAALTTTMT AAAKRPSDYR KLADAICSGD PTGAKKAAQD LLELANTSLM AVLVSQASRQ //