LOCUS       CAB5248286.1             286 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            PROTEASE TRANSMEMBRANE PROTEIN HEAT SHOCK PROTEIN HTPX
            protein.
ACCESSION   LT708304-585
PROTEIN_ID  CAB5248286.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="htpX"
                     /locus_tag="BQ2027_MB0578"
                     /note="Mb0578, htpX, len: 286 aa. Equivalent to Rv0563,
                     len: 286 aa (alternative start at position 654006), from
                     Mycobacterium tuberculosis strain H37Rv, (100.0% identity
                     in 286 aa overlap). Probable htpX, protease heat shock
                     protein X (EC 3.4.24.-) (transmembrane protein),
                     equivalent to NP_302484.1|NC_002677 putative peptidase
                     from Mycobacterium leprae (287 aa). Also highly similar to
                     others e.g. CAC08262.1|AL392146 putative peptidase from
                     Streptomyces coelicolor (287 aa); NP_387431.1|NC_003047
                     PUTATIVE PROTEASE TRANSMEMBRANE PROTEIN from Sinorhizobium
                     meliloti (319 aa); NP_105051.1|NC_002678 heat shock
                     protein (htpX) from Mesorhizobium loti (336 aa);
                     NP_248692.1|NC_000909|U67608|MJU67608_8 heat shock protein
                     HtpX, possibly protease (htpX) from Methanococcus
                     jannaschii (284 aa), FASTA scores: opt: 660, E(): 0, (46.5
                     identity in 245 aa overlap). Continuation of MTCY25D10.42.
                     TBparse score is 0.887. BELONGS TO PEPTIDASE FAMILY M48
                     (ZINC METALLOPROTEASE). COFACTOR: Zinc. Protein product
                     from Mb0578 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb0578 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTWHPHANRL KTFLLLVGMS ALIVAVGALF GRTALMLAAL FAVGMNVYVY FNSDKLALRA
       61 MHAQPVSELQ APAMYRIVRE LATSAHQPMP RLYISDTAAP NAFATGRNPR NAAVCCTTGI
      121 LRILNERELR AVLGHELSHV YNRDILISCV AGALAAVITA LANMAMWAGM FGGNRDNANP
      181 FALLLVALLG PIAATVIRMA VSRSREYQAD ESGAVLTGDP LALASALRKI SGGVQAAPLP
      241 PEPQLASQAH LMIANPFRAG ERIGSLFSTH PPIEDRIRRL EAMARG
//