LOCUS       CAB5248261.1             210 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            DOLICHYL-PHOSPHATE SUGAR SYNTHASE (DOLICHOL-PHOSPHATE
            SUGAR SYNTHETASE) (DOLICHOL-PHOSPHATE SUGAR TRANSFERASE)
            (SUGAR PHOSPHORYLDOLICHOL SYNTHASE) protein.
ACCESSION   LT708304-560
PROTEIN_ID  CAB5248261.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0553"
                     /note="Mb0553, -, len: 210 aa. Equivalent to Rv0539, len:
                     210 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 210 aa overlap). Probable
                     dolichol-P-sugar synthase (EC 2.4.1.-), highly similar to
                     CAB76989.1|AL159178 putative glycosyltransferase from
                     Streptomyces coelicolor (242 aa), and similar to various
                     dolichol-P-sugar synthetases and sugar transferases e.g.
                     NP_126257.1|NC_000868 DOLICHYL-PHOSPHATE MANNOSE SYNTHASE
                     RELATED PROTEIN from Pyrococcus abyssi (211 aa);
                     N-terminus of NP_127133.1|NC_000868 DOLICHOL-P-GLUCOSE
                     SYNTHETASE from Pyrococcus abyssi (378 aa); N-terminus of
                     NP_068880.1|NC_000917 putative dolichol-P-glucose
                     synthetase from Archaeoglobus fulgidus (369 aa), FASTA
                     scores: E(): 2.4e-13, (32. 1% identity in 193 aa overlap);
                     Q26732 DOLICHYL-PHOSPHATE-MANNOSE SYNTHASE PRECURSOR from
                     TRYPANOSOMA BRUCEI (267 aa), FASTA scores: opt: 179, E():
                     0.0011, (30.7% identity in 205 aa overlap); etc. Also
                     similar to Rv2051c|MTY25D10_18 from Mycobacterium
                     tuberculosis. Contains S00017 ATP/GTP-binding site motif A
                     (P-loop). Protein product from Mb0553 detected using SWATH
                     mass spectrometry. Mb0553 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MLPCLNEEES LPAVLAAIPA GYRALVVDNN STDDTATVAA RHGAQVVVEP RPGYGSAVHA
       61 GVLAATTPIV AVIDADGSMD AGDLPKLVAE LDKGADLVTG RRRPVAGLHW PWVARVGTVV
      121 MSWRLRTRHR LPVHDIAPMR VARREALLDL GVVDRRSGYP LELLVRAAAA GWRVVELDVS
      181 YGPRTGGKSK VSGSLRGSII AILDFWKVIS
//