LOCUS CAB5248253.1 581 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PE- PGRS FAMILY PROTEIN [FIRST PART] protein. ACCESSION LT708304-552 PROTEIN_ID CAB5248253.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="PE_PGRS6a" /locus_tag="BQ2027_MB0545" /note="Mb0545, PE_PGRS6a, len: 581 aa. Equivalent to 5' end of Rv0532, len: 594 aa, from Mycobacterium tuberculosis strain H37Rv, (92.7% identity in 564 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to others e.g. Y0DP_MYCTU|Q50615 from Mycobacterium tuberculosis (498 aa), FASTA scores: opt: 1703, E(): 0, (58.2% identity in 536 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS6 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits PE_PGRS6 into 2 parts, PE_PGRS6a and PE_PGRS6b, resulting in PE_PGRS6a having a different COOH part. There is also a 84 bp and a 9 bp (*-cggggccgg) insertion in PE_PGRS6a." BEGIN 1 MSNLLVTPEL VAAAAADLAG IGSAIGAANA AAGAPTMALL AAGADEVSAA VAAVFSSYAQ 61 QYQALSAAAA AFHDQFVRAL AAGAGAYAGA EAANVEQQLL NAINAPTLAL LGRPLIGNGA 121 DGAAGTGQAG GAGGLLYGNG GNGGSGAAGQ AGGAGGAAGL IGHGGTGGVG GTGAAGGAGG 181 TGGWLFGNGG AGGTGGAVTG VSTTGGPGGH GGDAGLYGFG GAGGAGGFGQ SGAAGGAGGA 241 GGAGGWLYGD GGDGGAGGNG GNESGTGVSG VGGVGGAGGA GGLLFGNGGD GGVGGDGGDG 301 SSTQDSGGDG GAGGAGGAGG WLLGNGGAGG AGGAASIKVA TGGLGGDGGD AGLFGFGGDG 361 GWGGRGVDAR FGAAGGAAGA GGAGGWLYGD GGAGGVGGVG GAVFSLSSGD GGAGGAGGGG 421 GWLFGNGGDG GAGGGGGGRF GSGSGAGGDG AVGGAGGAGA WFGNGGAGGV GGGGGRGTTA 481 IGGDGGAGGA GGAGGWLYGD GGAGGAGGGG GRGGTGNDGG DGGDGGRGGD AQLLGNGGDG 541 GAGGAGGPAG FGASPGAGAA GGGGGAGGSL FGSPGTTGPH G //