LOCUS CAB5248246.1 216 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE THIOREDOXIN PROTEIN (THIOL-DISULFIDE INTERCHANGE PROTEIN) protein. ACCESSION LT708304-545 PROTEIN_ID CAB5248246.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB0539" /note="Mb0539, -, len: 216 aa. Equivalent to Rv0526, len: 216 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 216 aa overlap). Possible thioredoxin protein (thiol-disulfide interchange protein) (EC 1.-.-.-), equivalent to Q49816|U2168C|S72901 hypothetical protein from Mycobacterium leprae (216 aa), FASTA scores: opt: 1144, E(): 0, (78.5% identity in 214 aa overlap). C-terminus shows some similarity to C-terminus of thioredoxins e.g. RESA_BACSU|P35160 resa protein from Bacillus subtilis (181 aa), FASTA scores: opt: 200, E(): 7.4e-06, (24.2% identity in 132 aa overlap); etc. Also similar to Mycobacterium tuberculosis thioredoxin-like proteins Rv1470, Rv1471, Rv1677, etc. Contains PS00194 Thioredoxin family active site. SEEMS TO BELONG TO THE THIOREDOXIN FAMILY. Protein product from Mb0539 detected using SWATH mass spectrometry. Mb0539 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." BEGIN 1 MQSRATRRSG ALTMRRLVIA AAVSALLLTG CSGRDAVAQG GTFEFVSPGG KTDIFYDPPA 61 SRGRPGPLSG PELADPARSV SLDDFPGQVV VVNVWGQWCG PCRAEVSQLQ RVYDATRGAG 121 VSFLGIDVRD NNRQAPQDFI NDRHVTYPSI YDPAMRTLIA FGGKYPTSVI PSTLVLDRQH 181 RVAAVFLREL LAADLQPVVE RVAEEEPSGR APVGAQ //