LOCUS       CAB5248246.1             216 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            THIOREDOXIN PROTEIN (THIOL-DISULFIDE INTERCHANGE PROTEIN)
            protein.
ACCESSION   LT708304-545
PROTEIN_ID  CAB5248246.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0539"
                     /note="Mb0539, -, len: 216 aa. Equivalent to Rv0526, len:
                     216 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 216 aa overlap). Possible thioredoxin
                     protein (thiol-disulfide interchange protein) (EC
                     1.-.-.-), equivalent to Q49816|U2168C|S72901 hypothetical
                     protein from Mycobacterium leprae (216 aa), FASTA scores:
                     opt: 1144, E(): 0, (78.5% identity in 214 aa overlap).
                     C-terminus shows some similarity to C-terminus of
                     thioredoxins e.g. RESA_BACSU|P35160 resa protein from
                     Bacillus subtilis (181 aa), FASTA scores: opt: 200, E():
                     7.4e-06, (24.2% identity in 132 aa overlap); etc. Also
                     similar to Mycobacterium tuberculosis thioredoxin-like
                     proteins Rv1470, Rv1471, Rv1677, etc. Contains PS00194
                     Thioredoxin family active site. SEEMS TO BELONG TO THE
                     THIOREDOXIN FAMILY. Protein product from Mb0539 detected
                     using SWATH mass spectrometry. Mb0539 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
BEGIN
        1 MQSRATRRSG ALTMRRLVIA AAVSALLLTG CSGRDAVAQG GTFEFVSPGG KTDIFYDPPA
       61 SRGRPGPLSG PELADPARSV SLDDFPGQVV VVNVWGQWCG PCRAEVSQLQ RVYDATRGAG
      121 VSFLGIDVRD NNRQAPQDFI NDRHVTYPSI YDPAMRTLIA FGGKYPTSVI PSTLVLDRQH
      181 RVAAVFLREL LAADLQPVVE RVAEEEPSGR APVGAQ
//