LOCUS CAB5248242.1 434 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE GABA PERMEASE GABP (4-AMINO BUTYRATE TRANSPORT CARRIER) (GAMA-AMINOBUTYRATE PERMEASE) protein. ACCESSION LT708304-541 PROTEIN_ID CAB5248242.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="gabP" /locus_tag="BQ2027_MB0535" /note="Mb0535, gabP, len: 434 aa. Equivalent to Rv0522, len: 434 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 434 aa overlap). Probable gabP, GABA permease (gamma-aminobutyrate permease), integral membrane protein, highly similar to others e.g. GABP_ECOLI|P25527 gaba permease from Escherichia coli (466 aa), FASTA scores: opt: 1218, E(): 0, (44.3% identity in 424 aa overlap); etc. Also similar to other Mycobacterium tuberculosis permeases e.g. MTCY13E10.06c FASTA score: (34.4% identity in 407 aa overlap). Contains PS00218 Amino acid permeases signature. Overlaps and extends Rv0523c|MTCY25D10.01 from overlapping cosmid. BELONGS TO THE AMINO ACID PERMEASE FAMILY (APC FAMILY). Mb0535 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." BEGIN 1 MIAIGGVIGA GLFVGSGVVI RATGPAAFLT YALCGALIVL VMRMLGEMAA ANPSTGAFAD 61 YAAKALGGWA GFSVGWLYWY FWVIVVGFEA VAGGKVLTYW IDAPLWLASL CLMMMMTATN 121 LVSVSSFGEF EFWFAGVKVA TIVGFLVLGT AFAFGLLPGH GMDFSNLSAH GGFFPDGVGA 181 VFAAIVVAIF SMTGTEVVTI AAAEAPDPQR AVQRAMSTVV ARIVIFFVGS VFLLTVILPW 241 NSLELGASPY VAALRHMGIG GADQIMNAVV LTAVLSCLNS GLYTASRMLF VLAARQEAPA 301 QLVKVNRRGV PTFAIMGSSV VGFLCVIMAW VSPATVFVFL LNSSGAVILF VYLLIALSQI 361 VLRRQTSGQN LGVRMWLFPG LSIVTVTGIV AVLARMAFDY AARSQLWLSL LSWAVVVGCY 421 LVTTLVRRPL NRPW //