LOCUS       CAB5248242.1             434 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            GABA PERMEASE GABP (4-AMINO BUTYRATE TRANSPORT CARRIER)
            (GAMA-AMINOBUTYRATE PERMEASE) protein.
ACCESSION   LT708304-541
PROTEIN_ID  CAB5248242.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="gabP"
                     /locus_tag="BQ2027_MB0535"
                     /note="Mb0535, gabP, len: 434 aa. Equivalent to Rv0522,
                     len: 434 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 434 aa overlap). Probable gabP, GABA
                     permease (gamma-aminobutyrate permease), integral membrane
                     protein, highly similar to others e.g. GABP_ECOLI|P25527
                     gaba permease from Escherichia coli (466 aa), FASTA
                     scores: opt: 1218, E(): 0, (44.3% identity in 424 aa
                     overlap); etc. Also similar to other Mycobacterium
                     tuberculosis permeases e.g. MTCY13E10.06c FASTA score:
                     (34.4% identity in 407 aa overlap). Contains PS00218 Amino
                     acid permeases signature. Overlaps and extends
                     Rv0523c|MTCY25D10.01 from overlapping cosmid. BELONGS TO
                     THE AMINO ACID PERMEASE FAMILY (APC FAMILY). Mb0535 found
                     to be expressed during exponential growth in Sauton's
                     minimal media by RNA-sequencing (TPM > 20)."
BEGIN
        1 MIAIGGVIGA GLFVGSGVVI RATGPAAFLT YALCGALIVL VMRMLGEMAA ANPSTGAFAD
       61 YAAKALGGWA GFSVGWLYWY FWVIVVGFEA VAGGKVLTYW IDAPLWLASL CLMMMMTATN
      121 LVSVSSFGEF EFWFAGVKVA TIVGFLVLGT AFAFGLLPGH GMDFSNLSAH GGFFPDGVGA
      181 VFAAIVVAIF SMTGTEVVTI AAAEAPDPQR AVQRAMSTVV ARIVIFFVGS VFLLTVILPW
      241 NSLELGASPY VAALRHMGIG GADQIMNAVV LTAVLSCLNS GLYTASRMLF VLAARQEAPA
      301 QLVKVNRRGV PTFAIMGSSV VGFLCVIMAW VSPATVFVFL LNSSGAVILF VYLLIALSQI
      361 VLRRQTSGQN LGVRMWLFPG LSIVTVTGIV AVLARMAFDY AARSQLWLSL LSWAVVVGCY
      421 LVTTLVRRPL NRPW
//