LOCUS       CAB5248214.1             328 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Exopolyphosphatas
            e (EC protein.
ACCESSION   LT708304-513
PROTEIN_ID  CAB5248214.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ppx1"
                     /locus_tag="BQ2027_MB0507"
                     /EC_number="3.6.1.11"
                     /note="Mb0507, -, len: 328 aa. Equivalent to Rv0496, len:
                     328 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 328 aa overlap). Conserved
                     hypothetical protein, highly similar to
                     S72894|467046|AAA17230.1|U00018 exopolyphosphatase (EC
                     3.6.1.11) ppx from Mycobacterium leprae (406 aa), FASTA
                     scores: opt: 1902, E(): 0, (86.6% identity in 343 aa
                     overlap); and P54882|Y496_MYCLE|ML2434|13094008|CAC31951.1
                     |AL583925 HYPOTHETICAL 36.2 KDA PROTEIN from Mycobacterium
                     leprae (339 aa). Also highly similar to hypothetical
                     proteins and exopolyphosphatases e.g.
                     Q9X8H1|Y715_STRCO|SCE7.15c HYPOTHETICAL PROTEIN from
                     Streptomyces coelicolor (309 aa). C-terminal region
                     similar to CGU31224_1|Q46054 protein similar to ppx gene
                     product of Mycobacterium leprae from Cornybacterium
                     glutamicum (140 aa), FASTA scores: opt: 615, E(): 2.7e-33,
                     (70.9% identity in 134 aa overlap). Protein product from
                     Mb0507 detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb0507 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MVDAHRGGHP TPMSSTKATL RLAEATDSSG KITKRGADKL ISTIDEFAKI AISSGCAELM
       61 AFATSAVRDA ENSEDVLSRV RKETGVELQA LRGEDESRLT FLAVRRWYGW SAGRILNLDI
      121 GGGSLEVSSG VDEEPEIALS LPLGAGRLTR EWLPDDPPGR RRVAMLRDWL DAELAEPSVT
      181 VLEAGSPDLA VATSKTFRSL ARLTGAAPSM AGPRVKRTLT ANGLRQLIAF ISRMTAVDRA
      241 ELEGVSADRA PQIVAGALVA EASMRALSIE AVEICPWALR EGLILRKLDS EADGTALIES
      301 SSVHTSVRAV GGQPADRNAA NRSRGSKP
//