LOCUS       CAB5248185.1             286 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            mycolic acid synthase umaa protein.
ACCESSION   LT708304-484
PROTEIN_ID  CAB5248185.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="umaA1"
                     /locus_tag="BQ2027_MB0478"
                     /note="Mb0478, umaA1, len: 286 aa. Equivalent to Rv0469,
                     len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 286 aa overlap). Possible umaA1,
                     mycolic acid synthase (EC 2.-.-.-), highly similar to
                     CAC30854.1|AL583923 methyl mycolic acid synthase 1 from
                     Mycobacterium leprae (286 aa); and CAC31976.1|AL583925
                     Mycolic acid synthase from Mycobacterium leprae (295 aa),
                     FASTA scores: opt: 1402, E(): 0, (69.6% identity in 286 aa
                     overlap). Also very similar to mycobacterial
                     methyltransferases e.g. U77466|CmaD|MBU77466_1 (286 aa);
                     MTCY20H10.26c|Z92772|MTY20H10_27 (296 aa); highly similar
                     to CFA1_MYCTU|Q11195|U66108|MTU66108_1
                     cyclopropane-fatty-acyl-phospholipid synthase 1 (287 aa),
                     FASTA scores: opt: 1360, E(): 0, (67.8% identity in 286 aa
                     overlap) (see citation below); and very similar also to
                     methoxy mycolic acid synthase 1 from Mycobacterium
                     tuberculosis e.g. MTU66108_1 (286 aa). Protein product
                     from Mb0478 detected using shotgun mass spectrometry.
                     Mb0478 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
BEGIN
        1 MTELRPFYEE SQSIYDVSDE FFSLFLDPTM AYTCAYFERE DMTLEEAQNA KFDLALDKLH
       61 LEPGMTLLDI GCGWGGGLQR AIENYDVNVI GITLSRNQFE YSKAKLAKIP TERSVQVRLQ
      121 GWDEFTDKVD RIVSIGAFEA FKMERYAAFF ERSYDILPDD GRMLLHTILT YTQKQMHEMG
      181 VKVTMSDVRF MKFIGEEIFP GGQLPAQEDI FKFAQAADFS VEKVQLLQQH YARTLNIWAA
      241 NLEANKDRAI ALQSEEIYNK YMHYLTGCEH FFRKGISNVG QFTLTK
//