LOCUS       CAB5248166.1             236 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            TRANSCRIPTIONAL REGULATORY PROTEIN protein.
ACCESSION   LT708304-465
PROTEIN_ID  CAB5248166.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0460"
                     /note="Mb0460, -, len: 236 aa. Equivalent to Rv0452, len:
                     236 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 236 aa overlap). Possible
                     transcriptional regulator, similar to several putative
                     TetR-family transcriptional regulators from Streptomyces
                     coelicolor. Also similar in N-terminus to
                     U1740Y|U15183|MLU15183_33 from Mycobacterium leprae (67
                     aa), FASTA score: (76.1% identity in 67 aa overlap).
                     Contains probable helix-turn-helix motif at aa 44-65
                     (Score 1727, +5.07 SD). Protein product from Mb0460
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0460 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MRYPLAVAQL GFQRARTEEN KRQRAAALVE AARSLALETG VASVTLTAVA GRAGIHYSAV
       61 RRYFTSHKEV LLHLAAEGWA RWSGTVCEQL GEPGPMSAPR VAEALANGLA ADPLFCDLLA
      121 NLHLHLEQEV DVDRVIEVKR TSIAAVIALV DAIESALPAL GRSGAFDILL AAYSLAATLW
      181 QIANPPERLT DAYAEEPELL PPEWNLDFAA ALTRLLTATL LGLLAGSPCE CRSPTR
//