LOCUS CAB5248153.1 311 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable dehydrogenase/reductase protein. ACCESSION LT708304-452 PROTEIN_ID CAB5248153.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB0447C" /note="Mb0447c, -, len: 311 aa. Equivalent to Rv0439c, len: 311 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 311 aa overlap). Probable dehydrogenase/reductase (EC 1.-.-.-), equivalent to AL035159|MLCB1450_6|T44727 probable oxidoreductase from Mycobacterium leprae (304 aa), FASTA scores: opt: 1360, E(): 0, (69.2% identity in 302 aa overlap). Also highly similar to various oxidoreductases, generally dehydrogenases/reductases e.g. PA5031|C83017|9951320|AAG08416.1|AE004916_5|AE004916 probable short chain dehydrogenase from Pseudomonas aeruginosa (309 aa); Q03326|OXIR_STRAT PROBABLE OXIDOREDUCTASE from Streptomyces antibioticus (298 aa), FASTA scores: opt: 400, E(): 1.2e-18, (34.6% identity in 298 aa overlap); etc. Protein product from Mb0447c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0447c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." BEGIN 1 MTANDNKTRK WSAADVPDQS GRVVVVTGAN TGIGYHTAAV FADRGAHVVL AVRNLEKGNA 61 ARARIMAARP GAHVTLQQLD LCSLDSVRAA ADALRTAYPR IDVLINNAGV MWTPKQVTKD 121 GFELQFGTNH LGHFALTGLV LDHMLPVPGS RVVTVSSQGH RIHAAIHFDD LQWERRYNRV 181 AAYGQAKLAN LLFTYELQRR LGEAGKSTIA VAAHPGGSNT ELTRNLPRLI RPVATVLGPL 241 LFQSPEMGAL PTLRAATDPT TQGGQYYGPD GFGEQRGHPK VVQSSAQSHD KDLQRRLWTV 301 SEELTGVSFG V //