LOCUS       CAB5248153.1             311 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            dehydrogenase/reductase protein.
ACCESSION   LT708304-452
PROTEIN_ID  CAB5248153.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0447C"
                     /note="Mb0447c, -, len: 311 aa. Equivalent to Rv0439c,
                     len: 311 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 311 aa overlap). Probable
                     dehydrogenase/reductase (EC 1.-.-.-), equivalent to
                     AL035159|MLCB1450_6|T44727 probable oxidoreductase from
                     Mycobacterium leprae (304 aa), FASTA scores: opt: 1360,
                     E(): 0, (69.2% identity in 302 aa overlap). Also highly
                     similar to various oxidoreductases, generally
                     dehydrogenases/reductases e.g.
                     PA5031|C83017|9951320|AAG08416.1|AE004916_5|AE004916
                     probable short chain dehydrogenase from Pseudomonas
                     aeruginosa (309 aa); Q03326|OXIR_STRAT PROBABLE
                     OXIDOREDUCTASE from Streptomyces antibioticus (298 aa),
                     FASTA scores: opt: 400, E(): 1.2e-18, (34.6% identity in
                     298 aa overlap); etc. Protein product from Mb0447c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0447c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MTANDNKTRK WSAADVPDQS GRVVVVTGAN TGIGYHTAAV FADRGAHVVL AVRNLEKGNA
       61 ARARIMAARP GAHVTLQQLD LCSLDSVRAA ADALRTAYPR IDVLINNAGV MWTPKQVTKD
      121 GFELQFGTNH LGHFALTGLV LDHMLPVPGS RVVTVSSQGH RIHAAIHFDD LQWERRYNRV
      181 AAYGQAKLAN LLFTYELQRR LGEAGKSTIA VAAHPGGSNT ELTRNLPRLI RPVATVLGPL
      241 LFQSPEMGAL PTLRAATDPT TQGGQYYGPD GFGEQRGHPK VVQSSAQSHD KDLQRRLWTV
      301 SEELTGVSFG V
//