LOCUS CAB5248149.1 728 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PUTATIVE CONSERVED ATPASE protein. ACCESSION LT708304-448 PROTEIN_ID CAB5248149.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB0443C" /note="Mb0443c, -, len: 728 aa. Equivalent to Rv0435c, len: 728 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 728 aa overlap). Putative conserved ATPase (EC 3.6.1.-), similar to others e.g. SAV_SULAC|Q07590 sav protein involved in cell division from sulfolobus acidocaldarius (780 aa), FASTA scores: opt: 897, E(): 0, (34.5% identity in 693 aa overlap); NP_148637.1|7435761|B72479 transitional endoplasmic reticulum ATPase from Aeropyrum pernix (699 aa); etc. Also similar to Rv3610c and Rv2115c from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop), and PS00674 AAA-protein family signature. Protein product from Mb0443c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0443c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." BEGIN 1 MTHPDPARQL TLTARLNTSA VDSRRGVVRL HPNAIAALGI REWDAVSLTG SRTTAAVAGL 61 AAADTAVGTV LLDDVTLSNA GLREGTEVIV SPVTVYGARS VTLSGSTLAT QSVPPVTLRQ 121 ALLGKVMTVG DAVSLLPRDL GPGTSTSAAS RALAAAVGIS WTSELLTVTG VDPDGPVSVQ 181 PNSLVTWGAG VPAAMGTSTA GQVSISSPEI QIEELKGAQP QAAKLTEWLK LALDEPHLLQ 241 TLGAGTNLGV LVSGPAGVGK ATLVRAVCDG RRLVTLDGPE IGALAAGDRV KAVASAVQAV 301 RHEGGVLLIT DADALLPAAA EPVASLILSE LRTAVATAGV VLIATSARPD QLDARLRSPE 361 LCDRELGLPL PDAATRKSLL EALLNPVPTG DLNLDEIASR TPGFVVADLA ALVREAALRA 421 ASRASADGRP PMLHQDDLLG ALTVIRPLSR SASDEVTVGD VTLDDVGDMA AAKQALTEAV 481 LWPLQHPDTF ARLGVEPPRG VLLYGPPGCG KTFVVRALAS TGQLSVHAVK GSELMDKWVG 541 SSEKAVRELF RRARDSAPSL VFLDELDALA PRRGQSFDSG VSDRVVAALL TELDGIDPLR 601 DVVMLGATNR PDLIDPALLR PGRLERLVFV EPPDAAARRE ILRTAGKSIP LSSDVDLDEV 661 AAGLDGYSAA DCVALLREAA LTAMRRSIDA ANVTAADLAT ARETVRASLD PLQVASLRKF 721 GTKGDLRS //