LOCUS CAB5248137.1 547 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE THIAMINE BIOSYNTHESIS PROTEIN THIC protein. ACCESSION LT708304-436 PROTEIN_ID CAB5248137.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="thiC" /locus_tag="BQ2027_MB0431C" /note="Mb0431c, thiC, len: 547 aa. Equivalent to Rv0423c, len: 547 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 547 aa overlap). Probable thiC, thiamin biosynthesis protein, equivalent to Q9ZBL0|THIC_MYCLE|11279601|T44743|AL035159|MLCB1450_22 THIAMINE BIOSYNTHESIS PROTEIN from Mycobacterium leprae (547 aa), FASTA scores: opt: 3283, E(): 0, (90.1% identity in 547 aa overlap). Also highly similar to others e.g. P45740|THIC_BACSU THIAMIN BIOSYNTHESIS PROTEIN from Bacillus subtilis (590 aa), FASTA scores: opt: 2295, E(): 0, (65.2% identity in 580 aa overlap); P30136|THIC_ECOLI THIC PROTEIN from Escherichia coli strain K12 (631 aa), FASTA scores: opt: 2141, E(): 0, (62.1% identity in 568 aa overlap); etc. BELONGS TO THE THIC FAMILY. Protein product from Mb0431c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0431c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." BEGIN 1 MTITVEPSVT TGPIAGSAKA YREIEAPGSG ATLQVPFRRV HLSTGDHFDL YDTSGPYTDT 61 DTVIDLTAGL PHRPGVVRDR GTQLQRARAG EITAEMAFIA AREDMSAELV RDEVARGRAV 121 IPANHHHPES EPMIIGKAFA VKVNANIGNS AVTSSIAEEV DKMVWATRWG ADTIMDLSTG 181 KNIHETREWI LRNSPVPVGT VPIYQALEKV KGDPTELTWE IYRDTVIEQC EQGVDYMTVH 241 AGVLLRYVPL TAKRVTGIVS RGGSIMAAWC LAHHRESFLY TNFEELCDIF ARYDVTFSLG 301 DGLRPGSIAD ANDAAQFAEL RTLGELTKIA KAHGAQVMIE GPGHIPMHKI VENVRLEEEL 361 CEEAPFYTLG PLATDIAPAY DHITSAIGAA IIAQAGTAML CYVTPKEHLG LPDRKDVKDG 421 VIAYKIAAHA ADLAKGHPRA QERDDALSTA RFEFRWNDQF ALSLDPDTAR EFHDETLPAE 481 PAKTAHFCSM CGPKFCSMRI TQDVREYAAE HGLETEADIE AVLAAGMAEK SREFAEHGNR 541 VYLPITQ //