LOCUS       CAB5248137.1             547 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            THIAMINE BIOSYNTHESIS PROTEIN THIC protein.
ACCESSION   LT708304-436
PROTEIN_ID  CAB5248137.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="thiC"
                     /locus_tag="BQ2027_MB0431C"
                     /note="Mb0431c, thiC, len: 547 aa. Equivalent to Rv0423c,
                     len: 547 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 547 aa overlap). Probable thiC,
                     thiamin biosynthesis protein, equivalent to
                     Q9ZBL0|THIC_MYCLE|11279601|T44743|AL035159|MLCB1450_22
                     THIAMINE BIOSYNTHESIS PROTEIN from Mycobacterium leprae
                     (547 aa), FASTA scores: opt: 3283, E(): 0, (90.1% identity
                     in 547 aa overlap). Also highly similar to others e.g.
                     P45740|THIC_BACSU THIAMIN BIOSYNTHESIS PROTEIN from
                     Bacillus subtilis (590 aa), FASTA scores: opt: 2295, E():
                     0, (65.2% identity in 580 aa overlap); P30136|THIC_ECOLI
                     THIC PROTEIN from Escherichia coli strain K12 (631 aa),
                     FASTA scores: opt: 2141, E(): 0, (62.1% identity in 568 aa
                     overlap); etc. BELONGS TO THE THIC FAMILY. Protein product
                     from Mb0431c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb0431c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MTITVEPSVT TGPIAGSAKA YREIEAPGSG ATLQVPFRRV HLSTGDHFDL YDTSGPYTDT
       61 DTVIDLTAGL PHRPGVVRDR GTQLQRARAG EITAEMAFIA AREDMSAELV RDEVARGRAV
      121 IPANHHHPES EPMIIGKAFA VKVNANIGNS AVTSSIAEEV DKMVWATRWG ADTIMDLSTG
      181 KNIHETREWI LRNSPVPVGT VPIYQALEKV KGDPTELTWE IYRDTVIEQC EQGVDYMTVH
      241 AGVLLRYVPL TAKRVTGIVS RGGSIMAAWC LAHHRESFLY TNFEELCDIF ARYDVTFSLG
      301 DGLRPGSIAD ANDAAQFAEL RTLGELTKIA KAHGAQVMIE GPGHIPMHKI VENVRLEEEL
      361 CEEAPFYTLG PLATDIAPAY DHITSAIGAA IIAQAGTAML CYVTPKEHLG LPDRKDVKDG
      421 VIAYKIAAHA ADLAKGHPRA QERDDALSTA RFEFRWNDQF ALSLDPDTAR EFHDETLPAE
      481 PAKTAHFCSM CGPKFCSMRI TQDVREYAAE HGLETEADIE AVLAAGMAEK SREFAEHGNR
      541 VYLPITQ
//