LOCUS       CAB5248127.1             217 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            MUTATOR PROTEIN MUTT3 (7,8-DIHYDRO-8-OXOGUANINE-TRIPHOSPHATASE)
            (8-OXO-DGTPASE) (DGTP PYROPHOSPHOHYDROLASE) protein.
ACCESSION   LT708304-426
PROTEIN_ID  CAB5248127.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mutT3"
                     /locus_tag="BQ2027_MB0421"
                     /note="Mb0421, mutT3, len: 217 aa. Equivalent to Rv0413,
                     len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 217 aa overlap). Possible mutT3,
                     mutator protein (EC 3.6.1.-), showing some similarity with
                     e.g. MUTT_PROVU|P32090 mutator mutt protein from Proteus
                     vulgaris (112 aa), FASTA scores: opt: 151, E(): 0.0008,
                     (40.7% identity in 59 aa overlap). SEEMS TO BELONG TO THE
                     NUDIX HYDROLASE FAMILY. Protein product from Mb0421
                     detected using SWATH mass spectrometry. Mb0421 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
BEGIN
        1 MPSCPPAYSE QVRGDGDGWV VSDSGVAYWG RYGAAGLLLR APRPDGTPAV LLQHRALWSH
       61 QGGTWGLPGG ARDSHETPEQ TAVRESSEEA GLSAERLEVR ATVVTAEVCG VDDTHWTYTT
      121 VVADAGELLD TVPNRESAEL RWVAENEVAD LPLHPGFAAS WQRLRTAPAT VPLARCDERR
      181 QRLPRTIQIE AGVFLWCTPG DADQAPSPLG RRISSLL
//