LOCUS       CAB5248120.1             272 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 BETA
            LACTAMASE LIKE PROTEIN protein.
ACCESSION   LT708304-419
PROTEIN_ID  CAB5248120.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0414C"
                     /note="Mb0414c, -, len: 272 aa. Equivalent to Rv0406c,
                     len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 272 aa overlap). Beta-lactamase-like
                     protein, equivalent to AAD38170.1|AF152397_1
                     beta-lactamase-like protein from Mycobacterium phlei (243
                     aa); AL023514|MLCB4_8 hypothetical protein from
                     Mycobacterium leprae (251 aa), FASTA scores: opt: 1284,
                     E(): 0, (74.9% identity in 243 aa overlap); and
                     AAD38164.1|AF152394_2 beta-lactamase-like protein from
                     Mycobacterium avium (247 aa), FASTA scores: opt: 1301,
                     E(): 0, (74.2% identity in 244 aa overlap); etc. Also
                     slight similarity to others beta-lactamases and
                     hypothetical proteins e.g. P52700|BLA1_XANMA|628530|S45349
                     METALLO-BETA-LACTAMASE L1 PRECURSOR (BETA-LACTAMASE, TYPE
                     II) (PENICILLINASE) from Xanthomonas maltophilia (290 aa),
                     FASTA scores: (34.4% identity in 96 aa overlap). Protein
                     product from Mb0414c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0414c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
BEGIN
        1 MVATRGTRLA ALALAPRLAG MAELVQITDK VHLARGHAVN WVLVTDDTGV LLIDAGYPGD
       61 RAEVLASLNK LGYTPGDVRA IVLTHAHIDH LGSAIWFARE HSTPVYCHAE EVGHAKREYR
      121 ENASVFDVAL RSWRPRVAVW GIHLLRRGGL TGDGIPTAQP LTAEAAAGLP GQPMAIFTPG
      181 HTSGHCSYVV DGVLASGDAL ITGHPMLRHR GPQLLPAVFS HSQQNSIRSL AALALLETNI
      241 LAPGHGELWH GPIRKATDEA LERAQKSNHV FR
//