LOCUS CAB5248119.1 946 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE MEMBRANE BOUND POLYKETIDE SYNTHASE PKS6B [SECOND PART] protein. ACCESSION LT708304-418 PROTEIN_ID CAB5248119.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="pks6b" /locus_tag="BQ2027_MB0413" /note="Mb0413, pks6b, len: 946 aa. Equivalent to 3' end of Rv0405, len: 1402 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 945 aa overlap). Probable pks6, membrane-bound polyketide synthase, highly similar to others e.g. CAC29643.1|AL583917 putative polyketide synthase from Mycobacterium leprae (2103 aa); Y06K_MYCTU|Q10977 probable polyketide synthase (1876 aa), FASTA scores: opt: 2303, E(): 0, (38.7% identity in 1232 aa overlap); etc. Contains PS00606 Beta-ketoacyl synthases active site, 2 x PS00017 ATP/GTP-binding site motif A (P-loop), and PS00012 Phosphopantetheine attachment site. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, pks6 exists as a single gene. In Mycobacterium bovis, a frameshift due to single base insertion (*-g), splits pks6 into 2 parts, pks6a and pks6b. Protein product from Mb0413 detected using SWATH mass spectrometry. Mb0413 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." BEGIN 1 MLMVERGSLL PSGGFTEPNP AIPFTELGLR VVDELQEWPV VAGRPRRAGV SSFGFGGTNA 61 HVIVEEAGSV GADTVSGRAD VGGSGGGVVA WVISGKTASA LAAQAGRLGR YVRARPALDV 121 VDVGYSLVST RSVFDHRAVV VGQTRDELLA GLAGVVAGRP EAGVVCGVGK PAGKTAFVFA 181 GQGSQWLGMG SELYAAYPVF AEALDAVVDE LDRHLRYPLR DVIWGHDQDL LNTTEFAQPA 241 LFAVEVALYR LLMSWGVRPG LVLGHSVGEL AAAHVAGALC LPDAAMLVAA RGRLMQALPA 301 GGAMFAVQAR EDEVAPMLGH DVSIAAVNGP ASVVISGAHD AVSAIADRLR GQGRRVHRLA 361 VSHAFHSALM EPMIAEFTAV AAELSVGLPT IPVISNVTGQ LVADDFASAD YWARHIRAVV 421 RFGDSVRSAH CAGASRFIEV GPGGGLTSLI EASLADAQIV SVPTLRKDRP EPVSVMTAAA 481 QGFVSGMGLD WASVFSGYRP KRVELPTYAF QHQKFWLAPA PSVSDPTAAG QIGASDGGAE 541 LLASSGFAAR LAGRSADEQL AAAIEVVCEH AAAVLGRDGA AGLDAGQAFA DSGFNSLSAV 601 ELRNRLTAVT AVTLPATAIF DHPTPTELAQ YLITQIDGHG SSAAAAANPA ERIDALTDLF 661 LQACDAGRDA DGWKMVALAS NTRERMSSPV RNNVSKNVAL LADGISDVVV ICIPTLTVLS 721 DQREYRDIAN AMTGRHSVYS LTLPGFDSSD ALPQNADMIV ETVSNAIIDV VGGSCRFVLS 781 GYSSGGVLAY ALCSHLSVKH QRNPLGVALI DTYLPSQIAN PSMNEGFSPN DTGKGLSREV 841 IRVARMLNRL TATRLTAAAT YAAIFQAWEP GRSMAPVLNI VAKDRIATVE NLREERINRW 901 RTAAAEAAYS VAEVPGDHFG VMSTSSEAIA TEIHDWISGL VRGPHP //