LOCUS       CAB5248102.1             406 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            O-SUCCINYLHOMOSERINE SULFHYDRYLASE METZ (OSH SULFHYDRYLASE)
            protein.
ACCESSION   LT708304-401
PROTEIN_ID  CAB5248102.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="metZ"
                     /locus_tag="BQ2027_MB0397"
                     /note="Mb0397, metZ, len: 406 aa. Equivalent to Rv0391,
                     len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 406 aa overlap). Probable metZ,
                     O-succinylhomoserine sulfhydrylase (EC 4.2.99.-),
                     equivalent, but shorter 20 aa in N-terminus, to
                     AA18941.1|AL023514 O-succinylhomoserine sulfhydrylase from
                     Mycobacterium leprae (426 aa). Also highly similar to
                     others e.g. METZ_PSEAE|P55218 o-succinylhomoserine
                     sulfhydrylase from Pseudomonas aeruginosa (403 aa), FASTA
                     scores: opt: 1175, E(): 0, (47.2% identity in 392 aa
                     overlap); etc. BELONGS TO THE TRANS-SULFURATION ENZYMES
                     FAMILY. Could also be a cystathionine gamma-synthase (EC
                     4.2.99.9). Protein product from Mb0397 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb0397 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
BEGIN
        1 MTDESSVRTP KALPDGVSQA TVGVRGGMLR SGFEETAEAM YLTSGYVYGS AAVAEKSFAG
       61 ELDHYVYSRY GNPTVSVFEE RLRLIEGAPA AFATASGMAA VFTSLGALLG AGDRLVAARS
      121 LFGSCFVVCS EILPRWGVQT VFVDGDDLSQ WERALSVPTQ AVFFETPSNP MQSLVDIAAV
      181 TELAHAAGAK VVLDNVFATP LLQQGFPLGV DVVVYSGTKH IDGQGRVLGG AILGDREYID
      241 GPVQKLMRHT GPAMSAFNAW VLLKGLETLA IRVQHSNASA QRIAEFLNGH PSVRWVRYPY
      301 LPSHPQYDLA KRQMSGGGTV VTFALDCPED VAKQRAFEVL DKMRLIDISN NLGDAKSLVT
      361 HPATTTHRAM GPEGRAAIGL GDGVVRISVG LEDTDDLIAD IDRALS
//