LOCUS CAB5248096.1 848 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE ENDOPEPTIDASE ATP BINDING PROTEIN (CHAIN B) CLPB (CLPB PROTEIN) (HEAT SHOCK PROTEIN F84.1) protein. ACCESSION LT708304-395 PROTEIN_ID CAB5248096.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="clpB" /locus_tag="BQ2027_MB0391C" /standard_name="htpM" /note="Mb0391c, clpB, len: 848 aa. Equivalent to Rv0384c, len: 848 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 848 aa overlap). Probable clpB (alternate gene name: htpM), endopeptidase ATP-binding protein, chain B (EC 3.-.-.-), equivalent to AC32007.1|AL583925 heat shock protein from Mycobacterium leprae (848 aa). Also highly similar to others e.g. P53532|CLPB_CORGL|1163118|AAB49540.1|U43536|CGU43536_1 CLPB PROTEIN (heat-inducible expression) from Corynebacterium glutamicum (852 aa), FASTA scores: opt: 4113, E(): 0, (74.5% identity in 846 aa overlap); T36551|4753885|CAB42048.1|AL049754|clpB|SCOEDB|SCH10.39c probable ATP-dependent proteinase ATP-binding chain from Streptomyces coelicolor (853 aa); P03815|CLPB_ECOLI|1788943|AAC75641.1|AE000345 CLPB PROTEIN (HEAT SHOCK PROTEIN F84.1) from Escherichia coli strains K12 and O157:H7 (857 aa); etc. Also similar to Rv3596c|ClpC from Mycobacterium tuberculosis. Contains PS00870 and PS00871 Chaperonins clpA/B signatures and two PS000017 ATP/GTP-binding site motives A (P-loop). BELONGS TO THE CLPA/CLPB FAMILY. Contains probable coiled-coil domain from aa 411-503. Protein product from Mb0391c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0391c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /experiment="experimental evidence, no additional details recorded" BEGIN 1 MDSFNPTTKT QAALTAALQA ASTAGNPEIR PAHLLMALLT QNDGIAAPLL EAVGVEPATV 61 RAETQRLLDR LPQATGASTQ PQLSRESLAA ITTAQQLATE LDDEYVSTEH VMVGLATGDS 121 DVAKLLTGHG ASPQALREAF VKVRGSARVT SPEPEATYQA LQKYSTDLTA RAREGKLDPV 181 IGRDNEIRRV VQVLSRRTKN NPVLIGEPGV GKTAIVEGLA QRIVAGDVPE SLRDKTIVAL 241 DLGSMVAGSK YRGEFEERLK AVLDDIKNSA GQIITFIDEL HTIVGAGATG EGAMDAGNMI 301 KPMLARGELR LVGATTLDEY RKHIEKDAAL ERRFQQVYVG EPSVEDTIGI LRGLKDRYEV 361 HHGVRITDSA LVAAATLSDR YITARFLPDK AIDLVDEAAS RLRMEIDSRP VEIDEVERLV 421 RRLEIEEMAL SKEEDEASAE RLAKLRSELA DQKEKLAELT TRWQNEKNAI EIVRDLKEQL 481 EALRGESERA ERDGDLAKAA ELRYGRIPEV EKKLDAALPQ AQAREQVMLK EEVGPDDIAD 541 VVSAWTGIPA GRLLEGETAK LLRMEDELGK RVIGQKAAVT AVSDAVRRSR AGVSDPNRPT 601 GAFMFLGPTG VGKTELAKAL ADFLFDDERA MVRIDMSEYG EKHTVARLIG APPGYVGYEA 661 GGQLTEAVRR RPYTVVLFDE IEKAHPDVFD VLLQVLDEGR LTDGHGRTVD FRNTILILTS 721 NLGSGGSAEQ VLAAVRATFK PEFINRLDDV LIFEGLNPEE LVRIVDIQLA QLGKRLAQRR 781 LQLQVSLPAK RWLAQRGFDP VYGARPLRRL VQQAIGDQLA KMLLAGQVHD GDTVPVNVSP 841 DADSLILG //