LOCUS CAB5248092.1 183 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE RNA METHYLTRANSFERASE (RNA METHYLASE) protein. ACCESSION LT708304-391 PROTEIN_ID CAB5248092.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB0387C" /note="Mb0387c, -, len: 183 aa. Equivalent to Rv0380c, len: 183 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 183 aa overlap). Possible RNA methyltransferase (EC 2.1.1.-), equivalent to CAC32002.1|AL583925 possible RNA methyltransferase from Mycobacterium leprae (182 aa). Also some similarity with others methyltransferases e.g. P19396|TRMH_ECOLI|78514|JV0043 TRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE (TRNA METHYLTRANSFERASE) from Escherichia coli (229 aa), FASTA scores: opt: 227, E(): 1.4e-09, (28.9% identity in 166 aa overlap). Also similar to Rv0881, Rv3579c, Rv1644 from Mycobacterium tuberculosis. Protein product from Mb0387c detected using SWATH mass spectrometry. Mb0387c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." BEGIN 1 MLLRDGDARN VVDAYRYWTR EAIIADIDTR RHPLHVAIEN FGHDANIGSV VRTANAFAVH 61 TVHIVGRRRW NRRGAMVTDR YQRLCHHDST TGLLEFAAGA GLTVVAVDNV PGAARLEQTA 121 LPRECLLLFG QEGPGITDDA RAGAAVTVSI AQFGSTRSIN AGVAAGIAMH AWIRQHADLG 181 RAW //