LOCUS CAB5248091.1 71 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE PROTEIN TRANSPORT PROTEIN SECE2 protein. ACCESSION LT708304-390 PROTEIN_ID CAB5248091.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="secE2" /locus_tag="BQ2027_MB0386" /note="Mb0386, secE2, len: 71 aa. Equivalent to Rv0379, len: 71 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 71 aa overlap). Possible secE2, protein transport protein, showing similarity with P27340|S61G_SULSO|SECE PREPROTEIN TRANSLOCASE SECE SUBUNIT (PROTEIN TRANSPORT PROTEIN SEC61 GAMMA SUBUNIT HOMOLOG) from Sulfolobus acidocaldarius (65 aa), FASTA scores: opt: 79, E(): 4.7. (30.3% identity in 66 aa overlap); and hypothetical proteins e.g. Q9HPW4|VNG1446H HYPOTHETICAL PROTEIN from Halobacterium sp. strain NRC-1 (77 aa); Q9I794|PA0038 HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (71 aa); etc. Also highly similar to U85467|MTU85467_1 hypothetical Mycobacterium tuberculosis protein from a patient isolate (116 aa), FASTA scores: opt: 443, E(): 7.7e-29, (98.6% identity in 71 aa overlap). Note that for Rv0379|MTV036.14, a translation initiation region different to the one in U85467|MTU85467_1 was chosen. COULD BE A PART OF THE PROKARYOTIC PROTEIN TRANSLOCATION APPARATUS WHICH COMPRISE SECA|Rv3240c, SECD|Rv2587c, SECE|Rv0638, SECF|Rv2586c, SECG|Rv1440 AND SECY|Rv0732. Protein product from Mb0386 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0386 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." BEGIN 1 MSVYKVIDII GTSPTSWEQA AAEAVQRARD SVDDIRVARV IEQDMAVDSA GKITYRIKLE 61 VSFKMRPAQP R //