LOCUS CAB5248056.1 493 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 ISONIAZID INDUCTIBLE GENE PROTEIN INIC protein. ACCESSION LT708304-355 PROTEIN_ID CAB5248056.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="iniC" /locus_tag="BQ2027_MB0350" /note="Mb0350, iniC, len: 493 aa. Equivalent to Rv0343, len: 493 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 493 aa overlap). iniC, isoniazid-inducible gene, (see citations below). Shows slight similarity to P40983|YOR6_THER8 hypothetical protein (402 aa), FASTA scores: opt: 196, E(): 2.6e-05, (25.9% identity in 228 aa overlap). Also some similarity to upstream ORF Rv0342|iniA. Contains (PS00017) ATP/GTP-binding site motif A (P-loop). Note that the iniA gene is also induced by the antibiotic ethambutol, an agent that inhibits cell wall biosynthesis by a mechanism that is distinct from isoniazid. Protein product from Mb0350 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0350 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." BEGIN 1 MSTSDRVRAI LHATIQAYRG APAYRQRGDV FCQLDRIGAR LAEPLRIALA GTLKAGKSTL 61 VNALVGDDIA PTDATEATRI VTWFRHGPTP RVTANHRGGR RANVPITRRG GLSFDLRRIN 121 PAELIDLEVE WPAEELIDAT IVDTPGTSSL ACDASERTLR LLVPADGVPR VDAVVFLLRT 181 LNAADVALLK QIGGLVGGSV GALGIIGVAS RADEIGAGRI DAMLSANDVA KRFTRELNQM 241 GICQAVVPVS GLLALTARTL RQTEFIALRK LAGAERTELN RALLSVDRFV RRDSPLPVDA 301 GIRAQLLERF GMFGIRMSIA VLAAGVTDST GLAAELLERS GLVALRNVID QQFAQRSDML 361 KAHTALVSLR RFVQTHPVPA TPYVIADIDP LLADTHAFEE LRMLSLLPSR ATTLNDDEIA 421 SLRRIIGGSG TSAAARLGLD PANSREAPRA ALAAAQHWRR RAAHPLNDPF TTRACRAAVR 481 SAEAMVAEFS ARR //