LOCUS       CAB5248056.1             493 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 ISONIAZID
            INDUCTIBLE GENE PROTEIN INIC protein.
ACCESSION   LT708304-355
PROTEIN_ID  CAB5248056.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="iniC"
                     /locus_tag="BQ2027_MB0350"
                     /note="Mb0350, iniC, len: 493 aa. Equivalent to Rv0343,
                     len: 493 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 493 aa overlap). iniC,
                     isoniazid-inducible gene, (see citations below). Shows
                     slight similarity to P40983|YOR6_THER8 hypothetical
                     protein (402 aa), FASTA scores: opt: 196, E(): 2.6e-05,
                     (25.9% identity in 228 aa overlap). Also some similarity
                     to upstream ORF Rv0342|iniA. Contains (PS00017)
                     ATP/GTP-binding site motif A (P-loop). Note that the iniA
                     gene is also induced by the antibiotic ethambutol, an
                     agent that inhibits cell wall biosynthesis by a mechanism
                     that is distinct from isoniazid. Protein product from
                     Mb0350 detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb0350 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MSTSDRVRAI LHATIQAYRG APAYRQRGDV FCQLDRIGAR LAEPLRIALA GTLKAGKSTL
       61 VNALVGDDIA PTDATEATRI VTWFRHGPTP RVTANHRGGR RANVPITRRG GLSFDLRRIN
      121 PAELIDLEVE WPAEELIDAT IVDTPGTSSL ACDASERTLR LLVPADGVPR VDAVVFLLRT
      181 LNAADVALLK QIGGLVGGSV GALGIIGVAS RADEIGAGRI DAMLSANDVA KRFTRELNQM
      241 GICQAVVPVS GLLALTARTL RQTEFIALRK LAGAERTELN RALLSVDRFV RRDSPLPVDA
      301 GIRAQLLERF GMFGIRMSIA VLAAGVTDST GLAAELLERS GLVALRNVID QQFAQRSDML
      361 KAHTALVSLR RFVQTHPVPA TPYVIADIDP LLADTHAFEE LRMLSLLPSR ATTLNDDEIA
      421 SLRRIIGGSG TSAAARLGLD PANSREAPRA ALAAAQHWRR RAAHPLNDPF TTRACRAAVR
      481 SAEAMVAEFS ARR
//