LOCUS       CAB5248051.1             882 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            iron-sulfur-binding reductase protein.
ACCESSION   LT708304-350
PROTEIN_ID  CAB5248051.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0345C"
                     /note="Mb0345c, -, len: 882 aa. Equivalent to Rv0338c,
                     len: 882 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 882 aa overlap). Probable
                     iron-sulphur-binding reductase (EC 1.-.-.-), possibly
                     membrane-bound, equivalent to CAC32018.1|AL583925 probable
                     iron-sulphur-binding reductase from Mycobacterium leprae
                     (880 aa). Also highly similar to others e.g.
                     T36608|5019323|CAB44376.1|AL078610 probable
                     iron-sulfur-binding reductase from Streptomyces coelicolor
                     (760 aa), FASTA scores: opt: 1658, E(): 0, (49.9% identity
                     in 772 aa overlap); BAB07521.1|AP001520
                     iron-sulphur-binding reductase from Bacillus halodurans
                     (700 aa). Contains PS00070 Aldehyde dehydrogenases
                     cysteine active site and two of PS00198 4Fe-4S
                     ferredoxins, iron-sulfur binding region signature. First
                     of several possible start sites chosen. Protein product
                     from Mb0345c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb0345c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MTTQTLIRLI LGMSMTAVVG VFALRRVWWL YKLVMSGQPA SGRTDNLGTR IWTQISEVLG
       61 QRRLLKWSIP GLAHFFTMWG FFILLTVYIE AYGLLFEERF HIPVIGRWDA LGFLQDFFAT
      121 AVFLGITTFA IIRILRNPRE IGRSSRFYGS HNGGAWLVLL MIFNVIWTYV LVRGSAVNNG
      181 TLPYGNGAFL SQLFGAILRP LGQPANEIIE TTALLLHIGV MLAFLILVLH SKHLHIFLAP
      241 INVTFKRLPD GLGPLLPLEA DGKPIDFENP SEDAVFGRGK IEDFTWKGML DFATCTECGR
      301 CQSQCPAWNT GKPLSPKLVI MDLRDHWMAK APYILGQKDA SAGGEAGHQE HHHVPESGFG
      361 RVPGHGPEQA TRPLVGTEEQ GGVIDPDVLW SCVTCGACVE QCPVDIEHVD HIVDMRRYQV
      421 MMESEFPSEL SVLFKNLETK GNPWGQNASD RTNWIDEVDF DVPVYGQDVD SFDGYEYLFW
      481 VGCAGAYDDK AKKTTKAVAE LLAVAGVKYL VLGAGETCNG DSARRSGNEF LFQQLAQQAV
      541 ETLDGLFEGV ETVDRKIVVT CPHCFNTIGK EYRQLGANYT VLHHTQLLNR LVRDKRLVPV
      601 TPVSQDITYH DPCYLGRHNK VYEAPRELIG AAGASLTEMP RHADRSFCCG AGGARMWMEE
      661 HIGKRINHER VDEALATDAT AIATACPFCR VMVTDGVNDR QEEAGRSGVE VLDVAQVLLG
      721 SLDHDKAQLP AKGTAAKQAQ ERAPKAAPKA AAPVTPVEAP AEAPQAPAPA APAAPVKGLG
      781 MAAGAKRPGA KKAAPTPAAP AAPAAPVKGL GIAAGAKRPG AKKTPPPAPG LAEPAAQPQP
      841 EAKPQPEPAA PPKPQTDGDP AAPAAPVKGL GIARGARPPG KR
//