LOCUS       CAB5248040.1             449 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            CYTOCHROME P450 135A1 CYP135A1 protein.
ACCESSION   LT708304-339
PROTEIN_ID  CAB5248040.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cyp135A1"
                     /locus_tag="BQ2027_MB0334C"
                     /note="Mb0334c, cyp135A1, len: 449 aa. Equivalent to
                     Rv0327c, len: 449 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.8% identity in 449 aa overlap). Possible
                     cyp135A1, cytochrome P450 (EC 1.14.-.-), similar to
                     cytochrome P-450 monoxygenases and other cytochrome P-450
                     related enzymes e.g. FQ12609 PUTATIVE P450 MONOOXYGENASE
                     (EC 1.14.14.1) (506 aa), FASTA scores: opt: 276, E() :
                     1.7e-11, (27.9% identity in 433 aa overlap). Also similar
                     to other Mycobacterium tuberculosis proteins e.g.
                     MTV039.06|Rv0568 PUTATIVE CYTOCHROME P450 (472 aa);
                     MTCI5.10 cytochrome p450 FASTA score: (30.4% identity in
                     434 aa overlap). Contains cytochrome P450 cysteine
                     heme-iron ligand signature (PS00086). BELONGS TO THE
                     CYTOCHROME P450 FAMILY. Alternative start possible at
                     33706 but no RBS."
BEGIN
        1 MASTLTTGLP PGPRLPRYLQ SVLYLRFREW FLPAMHRKYG DVFSLRVPPY ADNLVVYTRP
       61 EHIKEIFAAD PRSLHAGEGN HILGFVMGEH SVLMTDEAEY ARMRSLLMPA FTRAALRGYR
      121 DMIASVAREH ITRWRPHATI NSLDHMNALT LDIILRVVFG VTDPKVKAEL TSRLQQIINI
      181 HPAILAGVPY PSLKRMNPWK RFFHNQTKID EILYREIASR RIDSDLTART DVLSRLLQTK
      241 DTPTKPLTDA ELRDQLITLL LAGHETTAAA LSWTLWELAH APEIQSQVVW AAVGGDDGFL
      301 EAVLKEGMRR HTVIASTARK VTAPAEIGGW RLPAGTVVNT SILLAHASEV SHPKPTEFRP
      361 SRFLDGSVAP NTWLPFGGGV RRCLGFGFAL TEGAVILQEI FRRFTITAAG PSKGETPLVR
      421 NITTVPKHGA HLRLIPQRRL GGLGDSDPP
//