LOCUS       CAB5248035.1             190 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE)
            protein.
ACCESSION   LT708304-334
PROTEIN_ID  CAB5248035.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="dcd"
                     /locus_tag="BQ2027_MB0329"
                     /note="Mb0329, dcd, len: 190 aa. Equivalent to Rv0321,
                     len: 190 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.5% identity in 190 aa overlap). Probable dcd
                     (alterrnate gene names: dus or paxA), deoxycytidine
                     triphosphate deaminase (EC 3.5.4.13), equivalent to
                     CAC32024.1|AL583925 probable deoxycytidine triphosphate
                     deaminase from Mycobacterium leprae (190 aa). Also highly
                     similar to others e.g.
                     Q9X8W0|DCD_STRCO|7480599|T36613|SCH35.46 DEOXYCYTIDINE
                     TRIPHOSPHATE DEAMINASE from Streptomyces coelicolor (191
                     aa); DCD_ECOLI|P28248|DUS|PAXA|B2065 DEOXYCYTIDINE
                     TRIPHOSPHATE DEAMINASE from Escherichia coli strain K12
                     (193 aa), FASTA scores: opt: 408, E(): 2.7e-21, (43.1%
                     identity in 188 aa overlap); etc. Contains PS00017
                     ATP/GTP-binding site motif A (P-loop). BELONGS TO THE DCTP
                     DEAMINASE FAMILY. Protein product from Mb0329 detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0329 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MLLSDRDLRA EISSGRLGID PFDDTLVQPS SIDVRLDCLF RVFNNTRYTH IDPAKQQDEL
       61 TSLVQPVDGE PFVLHPGEFV LGSTLELFTL PDNLAGRLEG KSSLGRLGLL THSTAGFIDP
      121 GFSGHITLEL SNVANLPITL WPGMKIGQLC MLRLTSPSEH PYGSSRAGSK YQGQRGPTPS
      181 RSCQNFIRST
//