LOCUS       CAB5248010.1             465 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            SULFATASE protein.
ACCESSION   LT708304-309
PROTEIN_ID  CAB5248010.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0304C"
                     /note="Mb0304c, -, len: 465 aa. Equivalent to Rv0296c,
                     len: 465 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 465 aa overlap). Probable sulfatase,
                     possibly an aryl-/steryl-sulfatase (EC 3.1.6.-) or a
                     sulfamidase (sulfohydrolase) (sulphamidase) (EC 3.10.1.-).
                     Similar to various hydrolases e.g.
                     AAG41945.1|AF304053_1|AF304053 heparan N-sulfatase from
                     Mus musculus (502 aa);
                     NP_061292.1|6851181|AAF29460.1|AF153827_1|AF153827
                     N-sulfoglucosamine sulfohydrolase (sulfamidase)
                     (sulphamidase) from Mus musculus (502 aa);
                     AAG17206.1|AF217203_1|AF217203 heparan sulfate sulfamidase
                     from Canis familiaris (507 aa); P08842|STS_HUMAN|1360652
                     STERYL-SULFATASE PRECURSOR (EC 3.1.6.2) (STEROID
                     SULFATASE) (STERYL-SULFATE SULFOHYDROLASE) (ARYLSULFATASE
                     C) (ASC) from Homo sapiens (583 aa); ARSB_FELCA|P33727
                     arylsulfatase B precursor (EC 3.1.6.1) (535 aa), FASTA
                     scores: opt: 231, E(): 1.7e-08, (30.3% identity in 261 aa
                     overlap). Also similarity with 4 others sulfatases in
                     Mycobacterium tuberculosis. Contains sulfatases signature
                     1 (PS00523). Note that previously known as atsG. Protein
                     product from Mb0304c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0304c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
BEGIN
        1 MTSERATGQR ENLLIVHWHD LGRYLGVYHH PDVYSPRLDR LAAEGILFTR AHATAPLCTP
       61 SRGSLFTGRY PQSNGLVGLA HHGWEYRTGV QTLPQLLSES GWYSALFGMQ HETSYPKRLG
      121 FDEFDVSNSY CEYVVAKAQD WLHNRVPALD GQRFLLTAGF FETHRPYPHE RYRPADSAAV
      181 ELPDYLPDTP EVRQDVAEFY GSIATADEAV GRLLDTLADT GLDASTWVVF VTDHGPAFPR
      241 AKSTLYDAGT GIALIIRPPT RRAMAPRVYD ELFSGVDLVP TLLDLLRLEV PADVEGVSHA
      301 PALLAPDTEN AAVRDHVYTA KTYHDSFDPI RAIRTKEYSY IENYAPRPLL DLPWDIQESP
      361 AGMAVAPLVK APRPQRELYD LRADPTETNN LLAGDDSTQG VAAIAADLAV RLHDWRQRTA
      421 DVIPSDFAGS RIAERYTETY LRIHRKTPTG RSAIAADRGI DEHCS
//