LOCUS       CAB5247997.1             538 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 esx
            conserved component eccb3. esx-3 type vii secretion system
            protein. possible membrane protein. protein.
ACCESSION   LT708304-296
PROTEIN_ID  CAB5247997.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="eccb3"
                     /locus_tag="BQ2027_MB0291"
                     /note="Mb0291, -, len: 538 aa. Equivalent to Rv0283, len:
                     538 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 538 aa overlap). Possible conserved
                     membrane protein, similar to several hypothetical
                     mycobacterial proteins e.g. Z94121|MTY15F10_16|Rv3895c
                     from Mycobacterium tuberculosis (495 aa), FASTA scores:
                     opt: 698, E(): 0, (37.6% identity in 492 aa overlap);
                     Rv1782; Rv3450c; Rv3869; and Y14967|MLCB628_16|MLCB628.17c
                     from Mycobacterium leprae (481 aa), FASTA scores: opt:
                     672, E(): 1.5e-31, (37.2% identity in 506 aa overlap).
                     Contains PS00017 ATP/GTP-binding site motif A (P-loop).
                     Protein product from Mb0291 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0291 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTNQQHDHDF DHDRRSFASR TPVNNNPDKV VYRRGFVTRH QVTGWRFVMR RIAAGIALHD
       61 TRMLVDPLRT QSRAVLMGVL IVITGLIGSF VFSLIRPNGQ AGSNAVLADR STAALYVRVG
      121 EQLHPVLNLT SARLIVGRPV SPTTVKSTEL DQFPRGNLIG IPGAPERMVQ NTSTDANWTV
      181 CDGLNAPSRG GADGVGVTVI AGPLEDTGAR AAALGPGQAV LVDSGAGTWL LWDGKRSPID
      241 LADHAVTSGL GLGADVPAPR IIASGLFNAI PEAPPLTAPI IPDAGNPASF GVPAPIGAVV
      301 SSYALKDSGK TISDTVQYYA VLPDGLQQIS PVLAAILRNN NSYGLQQPPR LGADEVAKLP
      361 VSRVLDTRRY PSEPVSLVDV TRDPVTCAYW SKPVGAATSS LTLLAGSALP VPDAVHTVEL
      421 VGAGNGGVAT RVALAAGTGY FTQTVGGGPD APGAGSLFWV SDTGVRYGID NEPQGVAGGG
      481 KAVEALGLNP PPVPIPWSVL SLFVPGPTLS RADALLAHDT LVPDSRPARP VSAEGGYR
//