LOCUS CAB5247991.1 868 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PE- PGRS FAMILY PROTEIN [FIRST PART] protein. ACCESSION LT708304-290 PROTEIN_ID CAB5247991.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="PE_PGRS3a" /locus_tag="BQ2027_MB0285C" /note="Mb0285c, PE_PGRS3a, len: 868 aa. Similar to 5' end of Rv0278c, len: 957 aa, from Mycobacterium tuberculosis strain H37Rv, (80.7% identity in 888 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins, similar to many e.g. Z95890|MTCY28_25|Rv1759c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 3849, E(): 0, (67.8% identity in 903 aa overlap). Contains PS00583 pfkB family of carbohydrate kinases signature 1. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS3 exists as a single gene. In Mycobacterium bovis, a 2780 bp insertion leads to an extra copy of PE_PGRS3. Also, a frameshift due to single base deletion (t-*), splits this extra copy of PE_PGRS3 into 2 parts, PE_PGRS3a and PE_PGRS3b. Mb0285c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." BEGIN 1 MSFVIAAPEV IAAAATDLAS LESSIAAANA AAAANTTALL AAGADEVSTA VAALFGAHGQ 61 AYQALSAQAQ AFHAQFTQAL TSGGGAYAAA EAAATSPLLA PINEFFLANT GRPLIGNGAN 121 GAPGTGADGA PGGWLIGNGG AGGSGAANNA VGGTGGTGGA GGASGLLGSG GAGGAGGVAT 181 NTGGIGGAGG TGGNAVLFGA GGAGGASTNT TGGAGGAGGD GGNAGLLFGA AGVGGAGGFA 241 LATTASGGAG GAGGAGGMFT DGGVGGVGGK GGFGGAGGAG GNGGLFGAGG TGGAGGTIGA 301 GVAGMGGAGG AGGAGGLFGA GGTGGSGGGG ATTGGDGGAG GAGGFGRTTG GIGGTGGNAG 361 LLNGSGGAGG AGGAAITGPG GTGGAGGIPG LIGNGGNGGD GGASVTGTGG NGGAGGNGVQ 421 IGNGGNGGSG GTGAAAGKAG LGGLGGQLIG LDGSNAPVST SVHTLQQAAL NVVNEPFQTL 481 TGRPLIGNGA NGTPGTGAAG GAGGWLFGNG GNGGHGATNT AATATGGAGG AGGILFGTGG 541 NGGTGGIATG AGGIGGAGGA GGVSLLIGSG GTGGNGGNSI GVAGIGGAGG RGGDAGLLFG 601 AAGTGGHGAA GGVPAGVGGA GGNGGLFANG GAGGAGGFNA AGGNGGNGGL FGTGGTGGAG 661 TNFGAGGNGG NGGLFGAGGT GGAAGSGGSG ITTGGGGHGG NAGLLSLGAS GGAGGSGGAS 721 SLAGGAGGTG GNGALLFGFG GAGGAGGHGG AALTSIQQGG AGGAGGNGGL LFGSAGAGGA 781 GGSGANALGA GTGGTGGDGG HAGVFGNGGD GGAGGFGAGT GGSGGVGGNA VLIGNGGNGG 841 NAGKAGATPG AGGTGGLLLG ENGLNGLP //