LOCUS       CAB5247981.1             397 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 ATP-
            dependent DNA ligase (EC protein.
ACCESSION   LT708304-280
PROTEIN_ID  CAB5247981.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0275C"
                     /EC_number="6.5.1.1"
                     /note="Mb0275c, -, len: 397 aa. Equivalent to Rv0269c,
                     len: 397 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 397 aa overlap). Conserved
                     hypothetical protein, highly similar to AL079355|SC4C6_19
                     hypothetical protein from Streptomyces coelicolor (341
                     aa), FASTA scores: opt: 1019, E(): 0, (46.5% identity in
                     344 aa overlap), and similar to other proteins e.g.
                     CAC49016.1|AL603644 putative ATP-dependent DNA ligase
                     protein from Sinorhizobium meliloti (636 aa); O34398 YKOU
                     PROTEIN from Bacillus subtilis (611 aa), FASTA score:
                     (27.2% identity in 283 aa overlap). Also similar to
                     proteins from Mycobacterium tuberculosis e.g. Rv3062,
                     Rv3731 (both DNA ligases), and Rv0938, Rv3730c. Protein
                     product from Mb0275c detected using SWATH mass
                     spectrometry. Mb0275c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MSRMAAPVSL DVHGRQVIVT HPGRVVFPAH NDRKGYTKFD LVRYYLAVAE GAMRGVAGRP
       61 MILKRFVKGI SAEAVFQKRA PANRPDWVDV AELHYASGRS AAEAVIHDAA GLAWVINLGC
      121 VDLNPHPVLA GDLDHPDELR VDLDPMPGVA WQRVVEVALV VREVLEDYGL TAWPKTSGSR
      181 GFHVYARIAP CWSFPQVRLA AQTVAREVER RLPDAATSRW WKEEREGVFV DFNQNAKDRT
      241 VASAYSVRAT PDARVSTPLH WEEVPGCDPA VFTMATVPSR LADIGDPWAG MDDAVGRLDR
      301 LLMLAEELGP PQKAQSAKPL IEIARAKTRA EAMAALDIWR DRYPGAAALL RPADVLVDGM
      361 RGPSSIWYRI RINLQHVPAD QRPPQEELIA DYSPWPR
//