LOCUS       CAB5247974.1             181 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 AMINOGLYCOSIDE
            2'-N-ACETYLTRANSFERASE AAC (AAC(2')-IC) protein.
ACCESSION   LT708304-273
PROTEIN_ID  CAB5247974.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="aac"
                     /locus_tag="BQ2027_MB0268C"
                     /standard_name="aac(2')-IC"
                     /note="Mb0268c, aac, len: 181 aa. Equivalent to Rv0262c,
                     len: 181 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 181 aa overlap). aac, aminoglycoside
                     2'-N-acetyltransferase (aac(2')-IC) (EC 2.3.1.-) (see
                     citation below), highly similar to NP_302635.1|NC_002677
                     aminoglycoside 2'-N-acetyltransferase from Mycobacterium
                     leprae (182 aa); Q49157|AAC2_MYCFO|AAC aminoglycoside
                     2'-N-acetyltransferase from Mycobacterium fortuitum (195
                     aa), FASTA scores: opt: 884, E(): 0, (69.1% identity in
                     181 aa overlap); and P94968|AAC2_MYCSM|AAC aminoglycoside
                     2'-N-acetyltransferase from Mycobacterium smegmatis (210
                     aa) (see also citation below). Also similar to
                     Q52424|AAC2_PROST AMINOGLYCOSIDE 2'-N-ACETYLTRANSFERASE
                     from Providencia stuartii (178 aa). BELONGS TO THE
                     AAC(2')-I FAMILY OF ACETYLTRANSFERASES. Note that
                     previously known as aac(2')-IC. Protein product from
                     Mb0268c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb0268c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MHTQVHTARL VHTADLDSET RQDIRQMVTG AFAGDFTETD WEHTLGGMHA LIWHHGAIIA
       61 HAAVIQRRLI YRGNALRCGY VEGVAVRADW RGQRLVSALL DAVEQVMRGA YQLGALSSSA
      121 RARRLYASRG WLPWHGPTSV LAPTGPVRTP DDDGTVFVLP IDISLDTSAE LMCDWRAGDV
      181 W
//