LOCUS CAB5247973.1 469 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE INTEGRAL MEMBRANE NITRITE EXTRUSION PROTEIN NARK3 (NITRITE FACILITATOR) protein. ACCESSION LT708304-272 PROTEIN_ID CAB5247973.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="narK3" /locus_tag="BQ2027_MB0267C" /note="Mb0267c, narK3, len: 469 aa. Equivalent to Rv0261c, len: 469 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 469 aa overlap). Probable nirK3, nitrite extrusion protein, integral membrane protein possibly member of major facilitator superfamily (MFS), equivalent to AAB41700.1|U72744 nitrite extrusion protein from Mycobacterium fortuitum (471 aa); and 2342627|CAB11406.1|Z98741|T44908 nitrite extrusion protein homolog from Mycobacterium leprae (517 aa; longer in N-terminus). Also similar to other nitrite extrusion proteins e.g. NARK_ECOLI|P10903|B1223 nitrite extrusion protein 1 from Escherichia coli strain K12 (463 aa), FASTA scores: opt: 755, E(): 0, (35.0% identity in 466 aa overlap). BELONGS TO THE NARK/NASA FAMILY OF TRANSPORTERS." BEGIN 1 MGRSHQISDW DPEDSVAWEA GNKFIARRNL IWSVAAEHVG FSVWSLWSVM VLFMPTSVYG 61 FSAGDKFLLG ATATLVGACL RFPYTFATAK FGGRNWTIFS ALVLLIPTVG SILLLANPGL 121 PLWPYLVCGA LAGLGGGNFA ASMTNINAFF PQRLKGAALA LNAGGGNLGV PMVQLVGLLV 181 IATAGDREPY WVCAIYLVLL AVAGLGAALY MDNLTEYRIE LNTMRAVVSE PHTWVISLLY 241 IGTFGSFIGF SFAFGQVLQI NFIASGQSTA QASLHAAQIA FLGPLLGSLS RIYGGKLADR 301 IGGGRVTLAA FCAMLLATGI LISASTFGDH LAGPMPTATM VGYVIGFTAL FILSGIGNGS 361 VYKMIPSIFE ARSHSLQISE AERRQWSRSM SGALIGLAGA VGALGGVGVN LALRESYLTS 421 GTATSAFWAF GVFYLVASVL TWAIYVRRGL KSAGELVPAT TAPAGLAYV //