LOCUS       CAB5247966.1             174 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            bifunctional cobalamin biosynthesis protein cobu: cobinamide
            kinase + cobinamide phosphate guanylyltransferase protein.
ACCESSION   LT708304-265
PROTEIN_ID  CAB5247966.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cobU"
                     /locus_tag="BQ2027_MB0260C"
                     /note="Mb0260c, cobU, len: 174 aa. Equivalent to Rv0254c,
                     len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 174 aa overlap). Probable cobU,
                     cobalamin biosynthesis protein including a cobinamide
                     kinase (EC 2.-.-.-) and cobinamide phosphate
                     guanylyltransferase (EC 2.-.-.-). Highly similar to many
                     e.g. Q05599|COBU_SALTY COBINAMIDE KINASE / COBINAMIDE
                     PHOSPHATE GUANYLYLTRANSFERASE from Salmonella typhimurium
                     (181 aa), FASTA scores: opt: 308, E(): 1.1e-14, (38.7%
                     identity in 181 aa overlap);
                     P46886|COBU_ECOLI|B1993|Z3153|ECS2788 Bifunctional
                     cobalamin biosynthesis protein cobU from Escherichia coli
                     strains K12 and O157:H7 (181 aa); part of
                     AL096872|SC5F7_10 from Streptomyces coelicolor (397 aa),
                     FASTA scores: opt: 445, E(): 3.6e-23, (46.0% identity in
                     176 aa overlap); etc. Contains PS00017 ATP/GTP-binding
                     site motif A (P-loop). Protein product from Mb0260c
                     detected using SWATH mass spectrometry. Mb0260c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
BEGIN
        1 MRILVTGGVR SGKSTHAEAL LGDAADVVYV APGRPAAGSD PDWDARVALH RARRPPTWLT
       61 VETADVATAL SEARSPVLVD CLGTWLTAIM DGEALWSAAT ADVYAVLEAR LDGLCAALTG
      121 LPTAIVVTNE VGLGVVPSHS SGVLFRDLLG TINRRVAAVC DEVHLVIAGR VLKL
//