LOCUS CAB5247964.1 853 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE NITRITE REDUCTASE [NAD(P)H] LARGE SUBUNIT [FAD FLAVOPROTEIN] NIRB protein. ACCESSION LT708304-263 PROTEIN_ID CAB5247964.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="nirB" /locus_tag="BQ2027_MB0258" /note="Mb0258, nirB, len: 853 aa. Equivalent to Rv0252, len: 853 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 853 aa overlap). Probable nirB (alternate gene name: nasB), nitrite reductase [NAD(P)H] large subunit (EC 1.6.6.4), flavoprotein containing siroheme and a 2FE-2S iron-sulfur centre. Highly similar to many others bacterial enzymes e.g. P08201|NIRB_ECOLI NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT from Escherichia coli strain K12 (847 aa), FASTA scores: opt: 2775, E(): 0, (49.8% identity in 840 aa overlap); Q06458|NIRB_KLEPN NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT (957 aa), FASTA scores: opt: 2902, E(): 0, (54.2% identity in 827 aa overlap). Contains PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. HOMODIMER WHICH ASSOCIATES WITH NIRD|Rv0253. COFACTORS: FAD; Iron; Siroheme. Mb0258 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." BEGIN 1 MPTAGSSRAP AAAREIVVVG HGMVGHRLVE AVRARDADGS LRITVLAEEG DAAYDRVGLT 61 SYTESWDRAL LALPGNDYAG DQRVRLLLNT RVTQIDRATK SVVTAAGQRH RYDTLVLATG 121 SYAFVPPVPG HDLPACHVYR TFDDLDAIRA GAQRTLDGGH TDGGVVIGGG LLGLEAANAL 181 RQFGLQTHVV EMMPRLMAQQ IDEAGGALLA RMIADLGIAV HVGTGTESIE SVKHSDGSVW 241 ARVRLSDGEV IDAGVVIFAA GIRPRDELAR AAGLAIGDRG GVLTDLSCRT SDPDIYAVGE 301 VAAIDGRCYG LVGPGYTSAE VVADRLLDGS AEFPEADLST KLKLLGVDVA SFGDAMGATE 361 NCLEVVINDA VKRTYAKLVL SDDATTLLGG VLVGDASSYG VLRPMVGAEL PGDPLALIAP 421 AGSGAGAGAL GVGALPDSAQ ICSCNNVTKG ELKCAIADGC GDVPALKSCT AAGTSCGSCV 481 PLLKQLLEAE GVEQSKALCE HFSQSRAELF EIITATEVRT FSGLLDRFGR GKGCDICKPV 541 VASILASTGS DHILDGEQAS LQDSNDHFLA NIQKNGSYSV VPRVPGGDIK PEHLILIGQI 601 AQDFGLYTKI TGGQRIDLFG ARVDQLPLIW QRLVDGGMES GHAYGKAVRT VKSCVGSDWC 661 RYGQQDSVQL AIDLELRYRG LRAPHKIKLG VSGCARECAE ARGKDVGVIA TEKGWNLYVA 721 GNGGMTPKHA QLLASDLDKE TLIRYIDRFL IYYIRTADRL QRTAPWVESL GLDHVREVVC 781 EDSLGLAEEF EAAMQRHVAN YKCEWKGVLE DPDKLSRFVS FVNAPDAVDS TVTFTERAGR 841 KVPVSIGIPR VRS //