LOCUS       CAB5247964.1             853 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            NITRITE REDUCTASE [NAD(P)H] LARGE SUBUNIT [FAD FLAVOPROTEIN]
            NIRB protein.
ACCESSION   LT708304-263
PROTEIN_ID  CAB5247964.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="nirB"
                     /locus_tag="BQ2027_MB0258"
                     /note="Mb0258, nirB, len: 853 aa. Equivalent to Rv0252,
                     len: 853 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 853 aa overlap). Probable nirB
                     (alternate gene name: nasB), nitrite reductase [NAD(P)H]
                     large subunit (EC 1.6.6.4), flavoprotein containing
                     siroheme and a 2FE-2S iron-sulfur centre. Highly similar
                     to many others bacterial enzymes e.g. P08201|NIRB_ECOLI
                     NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT from Escherichia
                     coli strain K12 (847 aa), FASTA scores: opt: 2775, E(): 0,
                     (49.8% identity in 840 aa overlap); Q06458|NIRB_KLEPN
                     NITRITE REDUCTASE (NAD(P)H) LARGE SUBUNIT (957 aa), FASTA
                     scores: opt: 2902, E(): 0, (54.2% identity in 827 aa
                     overlap). Contains PS00365 Nitrite and sulfite reductases
                     iron-sulfur/siroheme-binding site. HOMODIMER WHICH
                     ASSOCIATES WITH NIRD|Rv0253. COFACTORS: FAD; Iron;
                     Siroheme. Mb0258 found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing (TPM >
                     20)."
BEGIN
        1 MPTAGSSRAP AAAREIVVVG HGMVGHRLVE AVRARDADGS LRITVLAEEG DAAYDRVGLT
       61 SYTESWDRAL LALPGNDYAG DQRVRLLLNT RVTQIDRATK SVVTAAGQRH RYDTLVLATG
      121 SYAFVPPVPG HDLPACHVYR TFDDLDAIRA GAQRTLDGGH TDGGVVIGGG LLGLEAANAL
      181 RQFGLQTHVV EMMPRLMAQQ IDEAGGALLA RMIADLGIAV HVGTGTESIE SVKHSDGSVW
      241 ARVRLSDGEV IDAGVVIFAA GIRPRDELAR AAGLAIGDRG GVLTDLSCRT SDPDIYAVGE
      301 VAAIDGRCYG LVGPGYTSAE VVADRLLDGS AEFPEADLST KLKLLGVDVA SFGDAMGATE
      361 NCLEVVINDA VKRTYAKLVL SDDATTLLGG VLVGDASSYG VLRPMVGAEL PGDPLALIAP
      421 AGSGAGAGAL GVGALPDSAQ ICSCNNVTKG ELKCAIADGC GDVPALKSCT AAGTSCGSCV
      481 PLLKQLLEAE GVEQSKALCE HFSQSRAELF EIITATEVRT FSGLLDRFGR GKGCDICKPV
      541 VASILASTGS DHILDGEQAS LQDSNDHFLA NIQKNGSYSV VPRVPGGDIK PEHLILIGQI
      601 AQDFGLYTKI TGGQRIDLFG ARVDQLPLIW QRLVDGGMES GHAYGKAVRT VKSCVGSDWC
      661 RYGQQDSVQL AIDLELRYRG LRAPHKIKLG VSGCARECAE ARGKDVGVIA TEKGWNLYVA
      721 GNGGMTPKHA QLLASDLDKE TLIRYIDRFL IYYIRTADRL QRTAPWVESL GLDHVREVVC
      781 EDSLGLAEEF EAAMQRHVAN YKCEWKGVLE DPDKLSRFVS FVNAPDAVDS TVTFTERAGR
      841 KVPVSIGIPR VRS
//