LOCUS       CAB5247953.1             280 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            3-hydroxyacyl-thioester dehydratase htdx protein.
ACCESSION   LT708304-252
PROTEIN_ID  CAB5247953.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="htdx"
                     /locus_tag="BQ2027_MB0247C"
                     /note="Mb0247c, -, len: 280 aa. Equivalent to Rv0241c,
                     len: 280 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 280 aa overlap). Conserved
                     hypothetical protein, highly similar to
                     MLCB1883.17c|T44876063881|CAA18566.1|AL022486 hypothetical
                     protein from Mycobacterium leprae (280 aa), FASTA scores:
                     opt: 1564, E(): 0, (81.8% identity in 280 aa overlap); and
                     CAC32097.1|AL583926 conserved hypothetical protein from
                     Mycobacterium leprae (300 aa). Also similar to proteins
                     from other organisms e.g. CAB77291.1|AL160312 putative
                     dehydratase from Streptomyces coelicolor (291 aa); part of
                     BAA92930.1|AB032743 fatty acid synthetase beta subunit
                     from Pichia angusta (2060 aa). Protein product from
                     Mb0247c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb0247c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTQPSGLKNL LRAAAGALPV VPRTDQLPNR TVTVEELPID PANVAAYAAV TGLRYGNQVP
       61 LTYPFALTFP SVMSLVTGFD FPFAAMGAIH TENHITQYRP IAVTDAVGVR VRAENLREHR
      121 RGLLVDLVTN VSVGNDVAWH QVTTFLHQQR TSLSGEPKPP PQKKPKLPPP AAVLRITPAK
      181 IRRYAAVGGD HNPIHTNPIA AKLFGFPTVI AHGMFTAAAV LANIEARFPD AVRYSVRFAK
      241 PVLLPATAGL YVAEGDGGWD LTLRNMAKGY PHLTATVRGL
//