LOCUS       CAB5247944.1             314 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 ribonucleoside-
            diphosphate reductase (beta chain) nrdb (ribonucleotide
            reductase small chain) protein.
ACCESSION   LT708304-243
PROTEIN_ID  CAB5247944.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="nrdB"
                     /locus_tag="BQ2027_MB0238"
                     /note="Mb0238, nrdB, len: 314 aa. Equivalent to Rv0233,
                     len: 314 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 314 aa overlap). Probable nrdB
                     (alternate gene name: rnrS) ribonucleoside-diphosphate
                     reductase, beta chain (EC 1.17.4.1), similar to others
                     e.g. RIR2_SCHPO|P36603 ribonucleoside-diphosphate
                     reductase (391 aa), FASTA scores: opt: 168, E(): 0.00018,
                     (26.1% identity in 199 aa overlap); etc. BELONGS TO THE
                     RIBONUCLEOSIDE DIPHOSPHATE REDUCTASE SMALL CHAIN FAMILY.
                     COFACTOR: BINDS 2 IRON IONS. Protein product from Mb0238
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0238 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
BEGIN
        1 MTRTRSGSLA AGGLNWASLP LKLFAGGNAK FWDPADIDFT RDRADWEKLS DDERDYATRL
       61 CTQFIAGEEA VTEDIQPFMS AMRAEGRLAD EMYLTQFAFE EAKHTQVFRM WLDAVGISED
      121 LHRYLDDLPA YRQIFYAELP ECLNALSADP SPAAQVRASV TYNHIVEGML ALTGYYAWHK
      181 ICVERAILPG MQELVRRIGD DERRHMAWGT FTCRRHVAAD DANWTVFETR MNELIPLALR
      241 LIEEGFALYG DQPPFDLSKD DFLQYSTDKG MRRFGTISNA RGRPVAEIDV DYSPAQLEDT
      301 FADEDRRTLA AASA
//