LOCUS       CAB5247934.1             385 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ALDEHYDE DEHYDROGENASE protein.
ACCESSION   LT708304-233
PROTEIN_ID  CAB5247934.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0228C"
                     /note="Mb0228c, -, len: 385 aa. Equivalent to Rv0223c,
                     len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (95.3% identity in 364 aa overlap). Probable aldehyde
                     dehydrogenase (EC 1.2.1.-), similar to others e.g.
                     A75608|6460525|AAF12231.1|AE001862_57 aldehyde
                     dehydrogenase from Deinococcus radiodurans strain R1 (495
                     aa); Q47943 L-sorbosone dehydrogenase NAD(P) dependent
                     from Gluconobacter oxydans (498 aa), FASTA scores: opt:
                     1157, E (): 0, (42.1% identity in 482 aa overlap); etc.
                     Also similar to Rv0768, Rv2858c, etc from Mycobacterium
                     tuberculosis. Contains PS00687 Aldehyde dehydrogenases
                     glutamic acid active site; and PS00070 Aldehyde
                     dehydrogenases cysteine active site. BELONGS TO THE
                     ALDEHYDE DEHYDROGENASES FAMILY.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     single base insertion (*-c) leads to a shorter product,
                     with a different COOH part compared to its homolog in
                     Mycobacterium tuberculosis strain H37Rv (385 aa versus 487
                     aa). Protein product from Mb0228c detected using shotgun
                     mass spectrometry and SWATH mass spectrometry. Mb0228c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
BEGIN
        1 MSDSATEYDK LFIGGKWTKP STSDVIEVRC PATGEYVGKV PMAAAADVDA AVAAARAAFD
       61 NGPWPSTPPH ERAAVIAAAV KMLAERKDLF TKLLAAETGQ PPTIIETMHW MGSMGAMNYF
      121 AGAADKVTWT ETRTGSYGQS IVSRESVGVV GAIVAWNVPL FLAVNKIAPA LLAGCTIVLK
      181 PAAETPLTAN ALAEVFAEVG LPEGVLSVVP GGIETGQALT SNPDIDMFTF TGSSAVGREV
      241 GRRAAEMLKP CTLELGGKSA AIILEDVDLA AAIPMMVFSG VMNAGQGCVN QTRILAPRSR
      301 YDEIVAAVTN FVTALPVGPP SDPAAQIGPL ISEKQRTRVE ALHRQGHRGG RSVGVRRRPS
      361 RGLGQRLLYP IHERRWRGKW HGQCG
//